S100B and NSE serum levels in patients with Parkinson's disease

Schaf, Débora V.; Tort, Adriano B.L.; Fricke, Daniele; Schestatsky, Pedro; Portela, Luis V.C.; Souza, Diogo O.; Rieder, Carlos R.M.

doi:10.1016/j.parkreldis.2004.07.002

« Previous Next »Parkinsonism & Related Disorders
Volume 11, Issue 1 , Pages 39-43, January 2005

S100B and NSE serum levels in patients with Parkinson's disease

Débora V. Schaf
- Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
- Phone:+55-51-33165557; fax:+55-51-33165540.
Adriano B.L. Tort
- Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
- Phone:+55-51-33165557; fax:+55-51-33165540.
Daniele Fricke
- Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos no 2350, zip code: 90035-003 Porto Alegre, RS, Brazil
Pedro Schestatsky
- Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos no 2350, zip code: 90035-003 Porto Alegre, RS, Brazil
Luis V.C. Portela
- Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
- Phone:+55-51-33165557; fax:+55-51-33165540.
Diogo O. Souza
- Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
- Phone:+55-51-33165557; fax:+55-51-33165540.
Carlos R.M. Rieder
- Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos no 2350, zip code: 90035-003 Porto Alegre, RS, Brazil
- Corresponding author. Tel.: +55-51-33168520; fax: +55-51-32225885.

Received 10 May 2004; received in revised form 1 July 2004; accepted 1 July 2004.

Abstract

We evaluated S100B protein and neuron-specific enolase (NSE) serum levels in Parkinson's disease (PD) patients and their correlation with the severity of disease. The levels of S100B (P=0.16) and NSE (P=0.39) between PD and controls were similar. However, S100B levels correlated positively with the Hoehn and Yahr scale (r=0.368; P=0.02) and negatively with the Activities of Daily Living (ADL) scale (r=−0.431; P=0.006). Therefore, S100B and NSE may not have a diagnostic role in PD, but S100B may have a potential role as a marker of disease progression. The study of S100B may also contribute to elucidate the controversial role of glial cells in PD.

Keywords: Parkinson's disease, S100B protein, Neuron-specific enolase, Neurodegenerative disorders, Biochemical markers