Parkinsonism & Related Disorders
Volume 11, Issue 1 , Pages 39-43 , January 2005

S100B and NSE serum levels in patients with Parkinson's disease

  • Débora V. Schaf

      Affiliations

    • Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
    • Phone:+55-51-33165557; fax:+55-51-33165540.
    • ,
  • Adriano B.L. Tort

      Affiliations

    • Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
    • Phone:+55-51-33165557; fax:+55-51-33165540.
    • ,
  • Daniele Fricke

      Affiliations

    • Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos no 2350, zip code: 90035-003 Porto Alegre, RS, Brazil
    • ,
  • Pedro Schestatsky

      Affiliations

    • Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos no 2350, zip code: 90035-003 Porto Alegre, RS, Brazil
    • ,
  • Luis V.C. Portela

      Affiliations

    • Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
    • Phone:+55-51-33165557; fax:+55-51-33165540.
    • ,
  • Diogo O. Souza

      Affiliations

    • Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, zip code: 90035-003 Porto Alegre, RS, Brazil
    • Phone:+55-51-33165557; fax:+55-51-33165540.
    • ,
  • Carlos R.M. Rieder

      Affiliations

    • Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos no 2350, zip code: 90035-003 Porto Alegre, RS, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-51-33168520; fax: +55-51-32225885.

Received 10 May 2004 ,Revised 1 July 2004 ,Accepted 1 July 2004.

References 

  1. Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci. 1973;20:415–455
  2. Carlsson A. Thirty years of dopamine research. Adv Neurol. 1993;60:1–10
  3. Hornykiewicz O. Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: possible neurochemical mechanisms. Adv Neurol. 1993;60:140–147
  4. Hirsch EC, Hunot S, Damier P, Faucheux B. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?. Ann Neurol. 1998;44(3 suppl 1):S115–S120
  5. Vila M, Jackson-Lewis V, Guegan C, Wu DC, Teismann P, Choi DK, et al. The role of glial cells in Parkinson's disease. Curr Opin Neurol. 2001;14(4):483–489
  6. McGeer PL, Itagaki S, Akiyama H, McGeer EG. Rate of cell death in parkinsonism indicates active neuropathological process. Ann Neurol. 1988;24:574–576
  7. Teismann P, Tieu K, Cohen O, Choi DK, Wu du C, Marks D, et al. Pathogenic role of glial cells in Parkinson's disease. Mov Disord. 2003;18(2):121–129
  8. Forno LS, DeLanney LE, Irwin I, Di Monte D, Langston JW. Astrocytes and Parkinson's disease. Prog Brain Res. 1992;94:429–436
  9. McGeer PL, McGeer EG. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer Dis Assoc Disord. 1998;12(suppl 2):S1–S6
  10. Damier P, Hirsch EC, Zhang P, Agid Y, Javoy-Agid F. Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience. 1993;52(1):1–6
  11. Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol. 2001;33(7):637–668
  12. Zimmer DB, Cornwall EH, Landar A, Song W. The S100 protein family: history, function, and expression. Brain Res Bull. 1995;37(4):417–429
  13. Marchi N, Rasmussen P, Kapural M, Fazio V, Kight K, Mayberg MR, et al. Peripheral markers of brain damage and blood-brain barrier dysfunction. Restor Neurol Neurosci. 2003;21(3–4):109–121
  14. Ingebrigtsen T, Waterloo K, Jacobsen EA, Langbakk B, Romner B. Traumatic brain damage in minor head injury: relation of serum S-100 protein measurements to magnetic resonance imaging and neurobehavioural outcome. Neurosurgery. 1999;45:468–475
  15. Herrmann M, Curio N, Jost S, Wunderlich MT, Synowitz H, Wallesch CW. Protein S-100B and neuron specific enolase as early neurobiochemical markers of the severity of traumatic brain injury. Restor Neurol Neurosci. 1999;14(2–3):109–114
  16. Wunderlich MT, Ebert AD, Kratz T, Goertler M, Jost S, Herrmann M. Early neurobehavioural outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke. 1999;30:1190–1195
  17. Sheng JG, Mrak RE, Rovnaghi C, Kozlowska E, Van Eldik LJ, Griffin WS. Human brain S100B and S100B mRNA expression increases with age: pathogenic implications for Alzheimer's disease. Neurobiol Aging. 1996;17:359–363
  18. Lara DR, Gama CS, Belmonte-de-Abreu P, Portela LVC, Gonçalves CA, Fonseca M, et al. Increased serum S100B protein in schizophrenia: a study in medication-free patients. J Psychiatr Res. 2001;35:11–14
  19. Walz R, Portela LVC, Tort ABL, Neto EC, Fernandes LN, Gonçalves CA, et al. Serum S100B levels in patients with HTLV-I associated myelopathy/tropical spastic paraparesis. Neurology. 2000;54:2021–2022
  20. Portela LV, Brenol JC, Walz R, Bianchin M, Tort AB, Canabarro UP, et al. Serum S100B levels in patients with lupus erythematosus: preliminary observation. Clin Diagn Lab Immunol. 2002;9:164–166
  21. Muramatsu Y, Kurosaki R, Watanabe H, Michimata M, Matsubara M, Imai Y, et al. Expression of S-100 protein is related to neuronal damage in MPTP-treated mice. Glia. 2003;42(3):307–313
  22. Persson L, Handemark HG, Gustafsson J, Rundstrom G, Mendel-Hartvig I, Esscher T, et al. S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system. Stroke. 1987;18:911–918
  23. Rabinowicz AL, Correale J, Boutros RB, Couldwell WT, Henderson CW, DeGiorgio CM. Neuron-specific enolase is increased after single seizures during inpatient video/EEG monitoring. Epilepsia. 1996;37(2):122–125
  24. Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol. 1999;56:33–39
  25. Hoehn MM, Yahr MD. Parkinsonism: onset, progression, and mortality. Neurology. 1967;17:427–442
  26. Schwab RS, England AC. In:  Gillingham FJ,  Donaldson MC editor. Projection technique for evaluating surgery in Parkinson's disease. Third Symposium on Parkinson's Disease. Edinburgh, UK: Livingstone; 1969;p. 152–157
  27. Folstein MF, Folstein S, Mchugh PR. Mini-mental state: a practical method for measuring the cognitive state of patients for the clinician. J Psychiatric Res. 1975;12:189–198
  28. Portela LV, Tort AB, Schaf DV, Ribeiro L, Nora DB, Walz R, et al. The serum S100B concentration is age dependent. Clin Chem. 2002;48(6 Pt 1):950–952
  29. Hirsch EC. Glial cells and Parkinson's disease. J Neurol. 2000;247(suppl 2):II58–II62
  30. Hirsch EC, Hunot S. Nitric oxide, glial cells and neuronal degeneration in parkinsonism. TiPS. 2000;21:163–165
  31. Hu J, Ferreira A, Van Eldik LJ. S100beta induces neuronal cell death through nitric oxide release from astrocytes. J Neurochem. 1997;69(6):2294–2301

PII: S1353-8020(04)00116-6

doi: 10.1016/j.parkreldis.2004.07.002

Parkinsonism & Related Disorders
Volume 11, Issue 1 , Pages 39-43 , January 2005

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