Parkinsonism & Related Disorders
Volume 13, Issue 2 , Pages 122-125 , March 2007

Three sisters with very-late-onset major depression and parkinsonism

  • GianPietro Sechi

      Affiliations

    • Institute of Neurology, University of Sassari, Sassari, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39079228362.
    • ,
  • Giovanni Antonio Cocco

      Affiliations

    • Institute of Neurology, University of Sassari, Sassari, Italy
    • ,
  • Alessandra Errigo

      Affiliations

    • Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    • ,
  • Luca Deiana

      Affiliations

    • Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    • ,
  • Giulio Rosati

      Affiliations

    • Institute of Neurology, University of Sassari, Sassari, Italy
    • ,
  • Virgilio Agnetti

      Affiliations

    • Institute of Neurology, University of Sassari, Sassari, Italy
    • ,
  • Kay Stephen Paulus

      Affiliations

    • Institute of Neurology, University of Sassari, Sassari, Italy
    • ,
  • Giovanni Mario Pes

      Affiliations

    • Department of Biomedical Sciences, University of Sassari, Sassari, Italy

Received 6 March 2006 ,Accepted 26 March 2006.

References 

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  2. Petrukhin K, Lutsenko S, Chernov I, Ross BM, Kaplan JH, Gilliam TC. Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions. Hum Mol Genet. 1994;3:1647–1656
  3. Ala A, Borjigin J, Rochwarger A, Schilsky M. Wilson disease in septuagenarian siblings: Raising the bar for diagnosis. Hepatology. 2005;41:668–670
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  5. Pankratz N, Nichols WC, Uniacke SK, Halter C, Rudolph A, Shults C, et al. Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations. Am J Hum Genet. 2002;71:124–135
  6. Schrag A, Jahanshahi M, Quinn NP. What contributes to depression in Parkinson's disease?. Psychol Med. 2001;31:65–73
  7. Barthel H, Hermann W, Kluge R, Hesse S, Collingridge DR, Wagner A, et al. Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease. AJNR Am J Neuroradiol. 2003;24:234–238
  8. Shimoji A, Miyakawa T, Watanabe K, Yamashita K, Katsuragi S, Kabashima K. Wilson's disease with extensive degeneration of cerebral white matter and cortex. Jpn J Psychiatry Neurol. 1987;41:709–717
  9. Paik SR, Shin HJ, Lee JH. Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide. Arch Biochem Biophys. 2000;15(378):269–277
  10. Sheline CT, Choi DW. Cu2+ toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo. Ann Neurol. 2004;55:645–653

PII: S1353-8020(06)00079-4

doi: 10.1016/j.parkreldis.2006.03.009

Parkinsonism & Related Disorders
Volume 13, Issue 2 , Pages 122-125 , March 2007

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