Stereotactic surgery for subthalamic nucleus stimulation under general anesthesia: A retrospective evaluation of Japanese patients with Parkinson's disease

Yamada, Kazumichi; Goto, Satoshi; Kuratsu, Jun-ichi; Matsuzaki, Kazuhito; Tamura, Tetsuya; Nagahiro, Shinji; Murase, Nagako; Shimazu, Hideki; Kaji, Ryuji

doi:10.1016/j.parkreldis.2006.07.008

« Previous Next »Parkinsonism & Related Disorders
Volume 13, Issue 2 , Pages 101-107, March 2007

Stereotactic surgery for subthalamic nucleus stimulation under general anesthesia: A retrospective evaluation of Japanese patients with Parkinson's disease

Kazumichi Yamada
- Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto City 860-8556, Kumamoto, Japan
- Corresponding author. Tel.: +81963735219; fax: +81963718064.
Satoshi Goto
- Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto City 860-8556, Kumamoto, Japan
Jun-ichi Kuratsu
- Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto City 860-8556, Kumamoto, Japan
Kazuhito Matsuzaki
- Department of Neurological Surgery, Graduate School of Medicine, The University of Tokushima, Japan
Tetsuya Tamura
- Department of Neurological Surgery, Graduate School of Medicine, The University of Tokushima, Japan
Shinji Nagahiro
- Department of Neurological Surgery, Graduate School of Medicine, The University of Tokushima, Japan
Nagako Murase
- Department of Clinical Neuroscience, Graduate School of Medicine, The University of Tokushima, Japan
Hideki Shimazu
- Department of Clinical Neuroscience, Graduate School of Medicine, The University of Tokushima, Japan
Ryuji Kaji
- Department of Clinical Neuroscience, Graduate School of Medicine, The University of Tokushima, Japan

Received 10 April 2006; received in revised form 20 June 2006; accepted 12 July 2006.

Abstract

We compared retrospectively the outcome of bilateral subthalamic nucleus (STN) stimulation in 15 patients with Parkinson's disease who underwent the procedure under general anesthesia (GA) with that achieved in 10 patients under local anesthesia (LA). At 3 months postoperatively, all cardinal parkinsonian motor symptoms, evaluated on Unified Parkinson's Disease Rating Scale were significantly improved compared to preoperative baselines in both groups. The administration of GA did not adversely affect postoperative improvements in motor and daily activity scores, except for off-medication bradykinesia. Our results suggest that GA compares favorably with LA in surgical procedure for bilateral STN stimulation.

Keywords: Anxiety, Deep brain stimulation, Drug-induced psychosis, General anesthesia, Parkinson's disease, Subthalamic nucleus