Subjective cognitive dysfunction associated with drug-induced parkinsonism in schizophrenia

Received 11 April 2007; received in revised form 12 July 2007; accepted 17 July 2007.

Abstract

The authors investigated the subjective cognitive dysfunction associated with drug-induced parkinsonism (DIP) among 58 stabilized schizophrenic outpatients. Subjective cognitive dysfunction was comprehensively assessed using the Frankfurt Complaint Questionnaire (FCQ). Multivariate analysis revealed that the DIP group scored significantly higher on the total FCQ score than the non-DIP group. In phenomenological subscale scores, the DIP group had significantly higher scores on “deterioration of discrimination”, “psychomotor disorder”, and “perceptual disorder” than the non-DIP group. These results suggest that DIP is significantly associated with subjective cognitive-perceptual dysfunction, reflecting the complex nature of DIP that includes motor and cognitive aspects.

Keywords: Drug-induced parkinsonism, Subjective cognitive dysfunction, Antipsychotics

a Department of Psychiatry, Gil Medical Center, Gachon University of Medicine and Science, 1198 Guwol-Dong, Namdong-Gu, Incheon 405-760, Korea

b Department of Psychiatry, Seoul Children's Hospital, Seoul, Korea

Corresponding author. Tel.: +82324603356; fax: +82324603434.

PII: S1353-8020(07)00124-1

doi:10.1016/j.parkreldis.2007.07.009

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