Concurrent validation of the 21-item and 6-item Hamilton Depression Rating Scale versus the DSM-IV diagnostic criteria to assess depression in patients with Parkinson's disease: An exploratory analysis

Abstract 

Objective

The concurrent validity of this 6-item version of Hamilton Depression Rating Scale (HDRS-6) compared to the original 21-item tool (HDRS-21), using the DSM-IV criteria for major depression as the gold standard in patients with Parkinson's disease.

Methods

In analytical study were analyzed: Cronbach's alpha (α C), item-total correlation, the receiver operating characteristic curve (ROC) and their area under the curve (AUC), Finally, used the Fagan nomogram.

Results

The 115-patient sample with mean illness duration of 7.15 years. HDRS-21 achieved an α C of 0.83, HDRS-6 a value of 0.68. Eleven of the HDRS-21 items failed to reach a minimum value. HDRS-21 obtained its better AUC capacity of 0.94 (cut/score of 18/19); HDRS-6 got an AUC of 0.92 (cut/score of 7/8). The Fagan nomogram was (89–94% and 83–90%, respectively).

Conclusions

Our results suggest that HDRS-6 is sufficient, valid and has a sound psychometric structure for use with Parkinson's disease patients.

Keywords: Parkinson's disease, Depression, Hamilton Depression Rating Scale, Validity