Parkinsonism & Related Disorders
Volume 15, Issue 1 , Pages 68-70, January 2009

A case of refractory secondary paroxysmal kinesigenic dyskinesia with high sensitivity to phenytoin monotherapy

Department of Neurology, Athens University Medical School, Eginition Hospital, 74 Vassilissis Sofias Avenue, 11528 Athens, Greece

Received 28 March 2007; received in revised form 22 January 2008; accepted 23 January 2008.

Abstract 

We report on a 42-year-old man with paroxysmal kinesigenic dyskinesia who was referred as a refractory case to any drug used in the past as monotherapy or in combination. Our decision to discontinue his current combined medication and to administer only high-dose phenytoin led to significant improvement. It is of interest to note that the previous use of phenytoin in combination with other antiepileptic and neuroleptic drugs had no effect. In addition, the co-administration of gabapentin led to a dramatic recurrence of the episodes.

Keywords: Epilepsy, Kinesigenic dyskinesia, Paroxysmal dyskinesia, Basal ganglia

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PII: S1353-8020(08)00042-4

doi:10.1016/j.parkreldis.2008.01.015

Parkinsonism & Related Disorders
Volume 15, Issue 1 , Pages 68-70, January 2009

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