Parkinsonism & Related Disorders
Volume 15, Issue 1 , Pages 64-67 , January 2009

Disrupted thalamic prefrontal pathways in patients with idiopathic dystonia

  • Leonardo Bonilha

      Affiliations

    • Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    • Murray Center for Research on Parkinson's Disease and Related Disorders, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Paulien M. de Vries

      Affiliations

    • Department of Neurology, Neuroimaging Center, Institute of Behavioral and Cognitive Neuroscience, University of Groningen, The Netherlands
    • ,
  • Mark W. Hurd

      Affiliations

    • Department of Radiology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Chris Rorden

      Affiliations

    • Department of Communication Sciences and Disorders, University of South Carolina, SC, USA
    • ,
  • Paul S. Morgan

      Affiliations

    • Department of Physics and Astronomy, University of South Carolina, SC, USA
    • ,
  • Nada Besenski

      Affiliations

    • Department of Radiology, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Kenneth J. Bergmann

      Affiliations

    • Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    • Murray Center for Research on Parkinson's Disease and Related Disorders, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Vanessa K. Hinson

      Affiliations

    • Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    • Murray Center for Research on Parkinson's Disease and Related Disorders, Medical University of South Carolina, Charleston, SC, USA
    • Corresponding Author InformationCorresponding author. Medical University of South Carolina, 326 Calhoun Street, Suite 308, Charleston, SC 29425, USA. Tel.: +1 843 792 3222; fax: +1 843 792 8626.

Received 12 October 2007 ,Revised 5 December 2007 ,Accepted 25 January 2008.

References 

  1. Draganski B, Thun-Hohenstein C, Bogdahn U, Winkler J, May A. “Motor circuit” gray matter changes in idiopathic cervical dystonia. Neurology. 2003;61:1228–1231
  2. Carbon M, Trost M, Ghilardi MF, Eidelberg D. Abnormal brain networks in primary torsion dystonia. Adv Neurol. 2004;94:155–161
  3. Eidelberg D, Moeller JR, Antonini A, Kazumata K, Nakamura T, Dhawan V, et al. Functional brain networks in DYT1 dystonia. Ann Neurol. 1998;44:303–312
  4. Eidelberg D. Brain networks and clinical penetrance: lessons from hyperkinetic movement disorders. Curr Opin Neurol. 2003;16:471–474
  5. Galardi G, Perani D, Grassi F, Bressi S, Amadio S, Antoni M, et al. Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis. Acta Neurol Scand. 1996;94:172–176
  6. Black KJ, Ongur D, Perlmutter JS. Putamen volume in idiopathic focal dystonia. Neurology. 1998;51:819–824
  7. Etgen T, Mühlau M, Gaser C, Sander D. Bilateral grey-matter increase in the putamen in primary blepharospasm. J Neurol Neurosurg Psychiatry. 2006;77:1017–1020
  8. Garraux G, Bauer A, Hanakawa T, Wu T, Kansaku K, Hallett M. Changes in brain anatomy in focal hand dystonia. Ann Neurol. 2004;55:736–739
  9. Carbon M, Kingsley PB, Su S, Smith GS, Spetsieris P, Bressman S, et al. Microstructural white matter changes in carriers of the DYT1 gene mutation. Ann Neurol. 2004;56:283–286
  10. Bonilha L, de Vries PM, Vincent DJ, Rorden C, Morgan PS, Hurd MW, et al. Structural white matter abnormalities in patients with idiopathic dystonia. Mov Disord. 2007;22:1110–1116
  11. Rorden C, Bonilha L, Nichols TE. Rank-order versus mean based statistics for neuroimaging. Neuroimage. 2007;35:1531–1537
  12. Vitek JL. Pathophysiology of dystonia: a neuronal model. Mov Disord. 2002;17(Suppl. 3):S49–S62

PII: S1353-8020(08)00045-X

doi: 10.1016/j.parkreldis.2008.01.018

Parkinsonism & Related Disorders
Volume 15, Issue 1 , Pages 64-67 , January 2009

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