Parkinsonism & Related Disorders
Volume 15, Issue 1 , Pages 24-29, January 2009

Vascular pathology in patients with idiopathic Parkinson's disease

Movement Disorders Centre and Stroke Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Pekarska 53, 656 91 Brno, Czech Republic

Received 14 May 2007; received in revised form 30 January 2008; accepted 12 February 2008.

Abstract 

To study the impact of brain vessel pathology on the clinical status of Parkinson's disease (PD), in 57 consecutive patients the clinical and neuropsychological data were compared with clinical MRI signs of vascular impairment and with the ultrasound brain vessel investigations. There was a significant correlation between clinical and cognitive status and intimomedial thickness, which is an indicator of large vessel impairment. Cognitive status was significantly related to the pulsatility index (an indicator of small vessel impairment). This study provides evidence that subclinical vascular pathology could influence the clinical status by contributing to motor and cognitive dysfunction in PD.

Keywords: Vascular, Parkinson's disease, Intimomedial thickness, Stroke, Pulsatility index, Cognitive

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1353-8020(08)00089-8

doi:10.1016/j.parkreldis.2008.02.007

Parkinsonism & Related Disorders
Volume 15, Issue 1 , Pages 24-29, January 2009

Article Tools