Parkinsonism & Related Disorders
Volume 15, Issue 8 , Pages 606-609 , September 2009

Grammar improvement following deep brain stimulation of the subthalamic and the pedunculopontine nuclei in advanced Parkinson's disease: A pilot study

  • Sergio Zanini

      Affiliations

    • Dipartimento di Patologia e Medicina Sperimentale e Clinica, University of Udine, Udine, Italy
    • Corresponding Author InformationCorrespondence to: Present address: Associazione “La Nostra Famiglia” – IRCCS “E. Medea” – Polo Regionale del Friuli Venezia-Giulia, Via Cialdini 29, 33037 Pasian di Prato (UD), Italy. Tel.: +39 0432 693111; fax: +39 0432 693106.
    • ,
  • Vincenzo Moschella

      Affiliations

    • Dipartimento di Neuroscienze, Tor Vergata University, Rome, Italy
    • ,
  • Alessandro Stefani

      Affiliations

    • Dipartimento di Neuroscienze, Tor Vergata University, Rome, Italy
    • IRCCS “Santa Lucia”, Rome, Italy
    • ,
  • Antonella Peppe

      Affiliations

    • IRCCS “Santa Lucia”, Rome, Italy
    • ,
  • Mariangela Pierantozzi

      Affiliations

    • Dipartimento di Neuroscienze, Tor Vergata University, Rome, Italy
    • ,
  • Salvatore Galati

      Affiliations

    • Dipartimento di Neuroscienze, Tor Vergata University, Rome, Italy
    • ,
  • Alberto Costa

      Affiliations

    • IRCCS “Santa Lucia”, Rome, Italy
    • ,
  • Paolo Mazzone

      Affiliations

    • Neurochirurgia Funzionale e Stereotassica, Ospedale CTO, Rome, Italy
    • ,
  • Paolo Stanzione

      Affiliations

    • Dipartimento di Neuroscienze, Tor Vergata University, Rome, Italy
    • IRCCS “Santa Lucia”, Rome, Italy

Received 2 April 2008 ,Revised 4 December 2008 ,Accepted 6 December 2008.

References 

  1. Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C, et al. Five-years follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med. 2003;349:1925–1934
  2. Parsons TD, Rogers SA, Braaten AJ, Woods SP, Tröster AI. Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta-analysis. Lancet Neurol. 2006;5:578–588
  3. Moretti R, Torre P, Antonello RM, Capus L, Zambito Marsala S, Cattaruzza T, et al. Neuropsychological changes after subthalamic nucleus stimulation: a 12 month follow-up in nine patients with Parkinson's disease. Parkinsonism Relat Disord. 2003;10:73–79
  4. Murray LL. Spoken language production in Huntington's and Parkinson's disease. J Speech Lang Hear Res. 2000;43:1350–1366
  5. Ullman MT. Contribution of memory circuits to language: the procedural/declarative model. Cognition. 2004;92:231–270
  6. Zanini S, Melatini A, Capus L, Gioulis M, Vassallo A, Bava A. Language recovery following subthalamic nucleus stimulation in Parkinson's disease. NeuroReport. 2003;14(3):511–516
  7. Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain. 2007;130:1596–1607
  8. Frank MJ. Hold your horses: a dynamic computational role for the subthalamic nucleus in decision making. Neural Netw. 2006;19:1120–1136
  9. Watson P, Montgomery EB. The relationship of neuronal activity within sensori-motor region of the subthalamic nucleus to speech. Brain Lang. 2006;97:233–240
  10. Aravamuthan BR, Muthusamy KA, Stein JF, Aziz TZ, Johansen-Berg H. Topography of cortical and subcortical connections of the human pedunculopontine and subthalamic nuclei. NeuroImage. 2007;37:694–705
  11. Galati S, Scarnati E, Mazzone P, Stanzione P, Stefani A. Deep brain stimulation promotes excitation and inhibition in subthalamic nucleus in Parkinson's disease. NeuroReport. 2008;19(6):661–666

PII: S1353-8020(08)00343-X

doi: 10.1016/j.parkreldis.2008.12.003

Parkinsonism & Related Disorders
Volume 15, Issue 8 , Pages 606-609 , September 2009

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