Parkinsonism & Related Disorders
Volume 15, Issue 9 , Pages 660-664, 5 November 2009

Diabetes preceding Parkinson's disease onset. A case–control study

Dipartimento Universitario di Neuroscienze Cliniche, Via Gaetano La Loggia 1, 90129 Palermo, Italy

Received 1 July 2008; received in revised form 23 February 2009; accepted 27 February 2009.

Abstract 

Objective

To assess the association between diabetes preceding Parkinson's disease (PD) and PD.

Methods

PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption.

Results

318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2–0.8).

Conclusions

Our findings provide additional support for a potential link between diabetes and PD.

Keywords: Parkinson's disease, Diabetes, Epidemiology, Case–control studies, Risk factors in epidemiology

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1353-8020(09)00062-5

doi:10.1016/j.parkreldis.2009.02.013

Parkinsonism & Related Disorders
Volume 15, Issue 9 , Pages 660-664, 5 November 2009