Parkinsonism & Related Disorders
Volume 15, Issue 9 , Pages 649-654 , 5 November 2009

A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human α-synuclein A30P+A53T transgenic mice

  • Kazuhiko Ono

      Affiliations

    • Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 92 871 6631; fax: +81 92 863 0389.
    • ,
  • Miyuki Ikemoto

      Affiliations

    • Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan
    • ,
  • Takeshi Kawarabayashi

      Affiliations

    • Department of Neurology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
    • ,
  • Masaki Ikeda

      Affiliations

    • Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan
    • ,
  • Takuya Nishinakagawa

      Affiliations

    • Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan
    • ,
  • Masato Hosokawa

      Affiliations

    • Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan
    • ,
  • Mikio Shoji

      Affiliations

    • Department of Neurology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
    • ,
  • Mitsuo Takahashi

      Affiliations

    • Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan
    • ,
  • Manabu Nakashima

      Affiliations

    • Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan

Received 18 November 2008 ,Revised 6 March 2009 ,Accepted 10 March 2009.

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PII: S1353-8020(09)00064-9

doi: 10.1016/j.parkreldis.2009.03.002

Parkinsonism & Related Disorders
Volume 15, Issue 9 , Pages 649-654 , 5 November 2009

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