Parkinsonism & Related Disorders
Volume 15, Issue 9 , Pages 640-643 , 5 November 2009

Performance on an Alzheimer-selective odor identification test in patients with Parkinson's disease and its relationship with cerebral dopamine transporter activity

  • Kelvin L. Chou

      Affiliations

    • Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    • Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA
    • Corresponding Author InformationCorresponding author. University of Michigan Medical School, 1500 E. Medical Center Drive, SPC 5316, 1914 Taubman Center, Ann Arbor, MI 48109-5316, USA. Tel.: +1 734 936 9045; fax: +1 734 936 8763.
    • ,
  • Nicolaas I. Bohnen

      Affiliations

    • Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    • Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    • Present address: Functional Neuroimaging, Cognitive and Mobility Laboratory, Departments of Radiology & Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.

Received 15 January 2009 ,Revised 16 February 2009 ,Accepted 12 March 2009.

References 

  1. Kranick SM, Duda JE. Olfactory dysfunction in Parkinson's disease. Neurosignals. 2008;16:35–40
  2. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging. 2003;24:197–211
  3. Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope. 1984;94:176–178
  4. Bohnen NI, Gedela S, Kuwabara H, Constantine GM, Mathis CA, Studenski SA, et al. Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease. J Neurol. 2007;254:84–90
  5. Bohnen NI, Gedela S, Herath P, Constantine GM, Moore RY. Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity. Neurosci Lett. 2008;447:12–16
  6. Hawkes CH, Shephard BC. Selective anosmia in Parkinson's disease?. Lancet. 1993;341:435–436
  7. Silveira-Moriyama L, Williams D, Katzenschlager R, Lees AJ. Pizza, mint, and licorice: smell testing in Parkinson's disease in a UK population. Mov Disord. 2005;20:S139
  8. Double KL, Rowe DB, Hayes M, Chan DK, Blackie J, Corbett A, et al. Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test. Arch Neurol. 2003;60:545–549
  9. Daum RF, Sekinger B, Kobal G, Lang CJ. Riechprufung mit “sniffin' sticks” zur klinischen Diagnostic des Morbus Parkinson. Nervenarzt. 2000;71:643–650
  10. Doty RL, Deems DA, Stellar S. Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology. 1988;38:1237–1244
  11. Boesveldt S, Verbaan D, Knol DL, Visser M, van Rooden SM, van Hilten JJ, et al. A comparative study of odor identification and odor discrimination deficits in Parkinson's disease. Mov Disord. 2008;23:1984–1990
  12. Wei CJ, Linster C, Cleland TA. Dopamine D(2) receptor activation modulates perceived odor intensity. Behav Neurosci. 2006;120:393–400
  13. Mesholam RI, Moberg PJ, Mahr RN, Doty RL. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol. 1998;55:84–90
  14. Tabert MH, Liu X, Doty RL, Serby M, Zamora D, Pelton GH, et al. A 10-item smell identification scale related to risk for Alzheimer's disease. Ann Neurol. 2005;58:155–160
  15. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55:181–184
  16. Folstein MF, Folstein SE, McHughMini-mental state PR. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198
  17. Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, et al. Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab. 2003;23:1096–1112
  18. Doty RL, Perl DP, Steele JC, Chen KM, Pierce JD, Reyes P, et al. Odor identification deficit of the parkinsonism–dementia complex of Guam: equivalence to that of Alzheimer's and idiopathic Parkinson's disease. Neurology. 1991;41:77–80discussion-1
  19. Kovacs T, Cairns NJ, Lantos PL. Olfactory centres in Alzheimer's disease: olfactory bulb is involved in early Braak's stages. Neuroreport. 2001;12:285–288
  20. Kareken DA, Mosnik DM, Doty RL, Dzemidzic M, Hutchins GD. Functional anatomy of human odor sensation, discrimination, and identification in health and aging. Neuropsychology. 2003;17:482–495
  21. Nakanishi S. Second-order neurones and receptor mechanisms in visual- and olfactory-information processing. Trends Neurosci. 1995;18:359–364
  22. Doty RL, Stern MB, Pfeiffer C, Gollomp SM, Hurtig HI. Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry. 1992;55:138–142
  23. Bohnen NI, Kaufer DI, Ivanco LS, Lopresti B, Koeppe RA, Davis JG, et al. Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. Arch Neurol. 2003;60:1745–1748
  24. Zaborszky L, Carlsen J, Brashear HR, Heimer L. Cholinergic and GABAergic afferents to the olfactory bulb in the rat with special emphasis on the projection neurons in the nucleus of the horizontal limb of the diagonal band. J Comp Neurol. 1986;243:488–509
  25. Linster C, Hasselmo ME. Neural activity in the horizontal limb of the diagonal band of broca can be modulated by electrical stimulation of the olfactory bulb and cortex in rats. Neurosci Lett. 2000;282:157–160
  26. Fletcher ML, Wilson DA. Experience modifies olfactory acuity: acetylcholine-dependent learning decreases behavioral generalization between similar odorants. J Neurosci. 2002;22:RC201
  27. Ravel N, Elaagouby A, Gervais R. Scopolamine injection into the olfactory bulb impairs short-term olfactory memory in rats. Behav Neurosci. 1994;108:317–324
  28. Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav. 1984;32:489–502
  29. Edison P, Rowe CC, Rinne JO, Ng S, Ahmed I, Kemppainen N, et al. Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry. 2008;79:1331–1338

PII: S1353-8020(09)00066-2

doi: 10.1016/j.parkreldis.2009.03.004

Parkinsonism & Related Disorders
Volume 15, Issue 9 , Pages 640-643 , 5 November 2009

Article Tools