Evaluation of gastric emptying in familial and sporadic Parkinson disease

Krygowska-Wajs, Anna; Cheshire, William P.; Wszolek, Zbigniew K.; Hubalewska-Dydejczyk, Alicja; Jasinska-Myga, Barbara; Farrer, Matthew J.; Moskala, Marek; Sowa-Staszczak, Anna

doi:10.1016/j.parkreldis.2009.04.003

« Previous Next »Parkinsonism & Related Disorders
Volume 15, Issue 9 , Pages 692-696, 5 November 2009

Evaluation of gastric emptying in familial and sporadic Parkinson disease☆

Anna Krygowska-Wajs
- Department of Neurology, Collegium Medicum Jagiellonian University, Krakow, Poland
- Corresponding author. Department of Neurology, Collegium Medicum Jagiellonian University, Botaniczna 3, Krakow 31-503, Poland. Tel./fax: +48 12 4248624.
William P. Cheshire Jr.
- Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
Zbigniew K. Wszolek
- Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
Alicja Hubalewska-Dydejczyk
- Department of Endocrinology, Nuclear Medicine Unit, Collegium Medicum Jagiellonian University, Krakow, Poland
Barbara Jasinska-Myga
- Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
- Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
- Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice, Poland
Matthew J. Farrer
- Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
Marek Moskala
- Department of Neurosurgery, Collegium Medicum Jagiellonian University, Krakow, Poland
Anna Sowa-Staszczak
- Department of Endocrinology, Nuclear Medicine Unit, Collegium Medicum Jagiellonian University, Krakow, Poland

Received 15 November 2008; received in revised form 27 March 2009; accepted 11 April 2009.

Abstract

Objective

To assess for the presence of gastric dysmotility in familial and sporadic Parkinson disease (PD).

Methods

10 subjects with familial Parkinson disease (fPD), 35 subjects with sporadic Parkinson disease (sPD), and 15 controls, all from academic tertiary care movement disorders centers, were studied. fPD was defined as the presence of at least 2 affected individuals within 2–3 consecutive generations in a family. Molecular genetic analysis has not revealed, thus far, any known genomic abnormality in these families. Gastric emptying was assessed by dynamic abdominal scintigraphy over 92 min following ingestion of a solid meal containing 99mTc-labeled colloid of 40 MBq activity. The main outcome measures were gastric emptying half-time and radiotracer activity over the gastric area at 46 and at 92 min.

Results

Gastric emptying time was delayed in 60% of subjects with PD. In comparison to mean t_1/2 of 38 ± 7 min in controls, mean t_1/2 was 58 ± 25 min in fPD (p = 0.02) and 46 ± 25 min in sPD (p = 0.10). Both fPD and sPD groups included subjects with delayed gastric emptying at an early stage of disease.

Conclusions

Patients with fPD showed significantly delayed gastric emptying in comparison to normal age-matched individuals. Further studies of gastrointestinal dysfunction in PD, particularly fPD, are warranted.

Keywords: Gastric emptying, Familial, Parkinson disease, Radionuclide imaging