Parkinsonism & Related Disorders
Volume 16, Issue 2 , Pages 132-135 , February 2010

Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor

  • Lorraine N. Clark

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, NY, USA
    • Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Center for Human Genetics, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Corresponding Author InformationCorresponding author. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, RB307 1150 St Nicholas Ave, New York, NY 10032, USA. Tel.: +1 212 851 5403.
    • ,
  • Sergey Kisselev

      Affiliations

    • Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • ,
  • Naeun Park

      Affiliations

    • Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • ,
  • Barbara Ross

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, NY, USA
    • ,
  • Miguel Verbitsky

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, NY, USA
    • ,
  • Eileen Rios

      Affiliations

    • Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • ,
  • Roy N. Alcalay

      Affiliations

    • Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • ,
  • Joseph H. Lee

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, NY, USA
    • Center for Human Genetics, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    • ,
  • Elan D. Louis

      Affiliations

    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, NY, USA
    • Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    • Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

Received 13 January 2009 ,Revised 14 May 2009 ,Accepted 17 May 2009.

References 

  1. Louis ED, Levy G, Mejia-Santana H, Cote L, Andrews H, Harris J, et al. Risk of action tremor in relatives of tremor-dominant and postural instability gait disorder PD. Neurology. 2003;61(7):931–936
  2. Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, Robinson CA, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain. 2007;130:3297–3307
  3. Paisan-Ruiz C, Jain S, Evans EW, Gilks WP, Simon J, van der Brug M, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron. 2004;44:595–600
  4. Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004;44:601–607
  5. Deng H, Le W, Davidson AL, Xie W, Jankovic J. The LRRK2 I2012T, G2019S, and I2020T mutations in patients with essential tremor. Neurosci Lett. 2006;407:97–100
  6. Deng H, Le w, Huang M, Xie W, Pan T, Janovic J. Genetic analysis of LRRK2 P755L variant in Caucasian patients with parkinson's disease. Neurosci Lett. 2007;419:104–107
  7. Tan EK, Lee J, Lim H-Q, Yuen Y, Zhao Y. Essential tremor and the common LRRK2 G2385R variant. Parkinsonism Relat Disord. 2008;14:569–571
  8. Vitale C, Ciotti P, Gulli R, Bellone E, Scaglione C, Abbruzzese G, et al. Common mutations in the LRRK2 exon 41 are not responsible for essential tremor in Italian patients. Parkinsonism Relat Disord. 2008 Jun 13;[Epub ahead of print]
  9. Rogaeva E, Hardy J. Gaucher and Parkinson diseases: unexpectedly related. Neurology. 2008;70(24):2272–2273
  10. Clark LN, Kartsaklis LA, Gilbert RW, Dorado B, Ross BM, Kisselev S, et al. Glucocerebrosidase mutations are associated with Dementia with Lewy bodies. Arch Neurol. 2009;66(5):578–583
  11. Louis ED, Jiang W, Pellegrino KM, Rios E, Factor-Litvak P, Henchcliffe C, et al. Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor. Neurotoxicology. 2008;29(2):294–300
  12. Clark LN, Karlins E, Wang Y, Mejia-Sanatana H, Harris J, Louis ED, et al. Frequency of LRRK2 mutations in Early and Late-Onset Parkinson's disease. Neurology. 2006;62:548–552

☆ The review of this paper was entirely handled by an Associate Editor, Rober Rodnitzky.

PII: S1353-8020(09)00134-5

doi: 10.1016/j.parkreldis.2009.05.008

Parkinsonism & Related Disorders
Volume 16, Issue 2 , Pages 132-135 , February 2010

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