Parkinsonism & Related Disorders
Volume 16, Issue 2 , Pages 136-138 , February 2010

Low frequency of the PARK2 gene mutations in Polish patients with the early-onset form of Parkinson disease

  • Dariusz Koziorowski

      Affiliations

    • Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland
    • Corresponding Author InformationCorresponding author. Tel./fax: +48 22 3265815.
    • ,
  • Dorota Hoffman-Zacharska

      Affiliations

    • Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland
    • ,
  • Jarosław Sławek

      Affiliations

    • Department of Neurological and Psychiatric Nursing, Medical University, Gdansk, Poland
    • Department of Neurology, St. Adalbert Hospital, Gdansk, Poland
    • ,
  • Walentyna Szirkowiec

      Affiliations

    • Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland
    • ,
  • Piotr Janik

      Affiliations

    • Department of Neurology, Medical University of Warsaw, Poland
    • ,
  • Jerzy Bal

      Affiliations

    • Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland
    • ,
  • Andrzej Friedman

      Affiliations

    • Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland

Received 15 March 2009 ,Revised 12 May 2009 ,Accepted 16 June 2009.

References 

  1. de Rijk MC, Tzurio C, Breteler MM, Dartigues JF, Amaducci L, Lopez-Pousa S, et al. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative study. European community concerned action on the epidemiology of Parkinson's disease. J Neurol Neurosurg Psychiatr. 1997;6(2):10–15
  2. Schrag A, Schott JM. Epidemiological, clinical and genetic characteristics of early onset parkinsonism. Lancet Neurol. 2006;5:355–363
  3. Tan EK, Skipper LM. Pathogenic mutation in Parkinson's disease. Hum Mutat. 2007;28:641–653
  4. Lucking CB, Durr A, Bonifati V, Vaughan J, De Michele G, Gasser T, et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. French Parkinson's disease Genetic Study Group. N Engl J Med. 2000;342:1560–1567
  5. Abbas N, Lucking CB, Ricard S, Dürr A, Bonifati V, De Michele G, et al. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. Hum Mol Genet. 1999;8:567–574
  6. Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology. 2001;57:1497–1499
  7. Hattori N, Kitada T, Matsumine H, Asakawa S, Yamamura Y, Yoshino H, et al. Molecular genetics analysis a novel parkin gene in Japanese families with autosomal recessive juvenile Parkinsonism: evidence for variable homozygous deletions in the parkin gene in affected individuals. Ann Neurol. 1998;44:935–941
  8. Sironi F, Primignani P, Zini M, Tunesi S, Ruffmann C, Ricca S, et al. Parkin analysis in early onset Parkinson's disease. Parkinsonism Relat Disord. 2008;14:326–333
  9. Hakansson A, Belin AC, Stiller C, Sydof O, Johnels B. Investigation of genes related to familial forms of Parkinson's disease – With focus on the Parkin gene. Parkinsonism Relat Disord. 2008;14:520–522
  10. Mellick GD, Siebert GA, Funayama M, Buchanan DD, Li Y, Imamichi Y, et al. Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia. Parkinsonism Relat Disord. 2009;1:105–109
  11. Choi JM, Woo MS, Ma HI, Kang SY, Sung YH, Yong SW, et al. Analysis of PARK genes in a Korean cohort of early-onset Parkinson's disease. Neurogenetics. 2008;9:263–269
  12. Schlitter AM, Kurz M, Larsen JP, Woitalla D, Müller T, Epplen JT, et al. Parkin gene variations in late-onset Parkinson's disease: comparison between Norwegian and German cohorts. Acta Neurol Scand. 2006;113:9–13

☆ The review of this paper was entirely handled by an Associate Editor, Jonathan carr.

PII: S1353-8020(09)00170-9

doi: 10.1016/j.parkreldis.2009.06.010

Parkinsonism & Related Disorders
Volume 16, Issue 2 , Pages 136-138 , February 2010

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