Parkinsonism & Related Disorders
Volume 16, Issue 3 , Pages 218-221 , March 2010

Eighteen month study of continuous intraduodenal levodopa infusion in patients with advanced Parkinson's disease: Impact on control of fluctuations and quality of life

  • V. Puente

      Affiliations

    • Neurology Department, Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 932 483 235; fax: +34 932 483 322.
    • ,
  • O. De Fabregues

      Affiliations

    • Neurology Department, Hospital de Sabadell-C.S. Parc Taulli, Sabadell, Spain
    • ,
  • C. Oliveras

      Affiliations

    • Neurology Department, Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    • ,
  • G. Ribera

      Affiliations

    • Neurology Department, Hospital de Sabadell-C.S. Parc Taulli, Sabadell, Spain
    • ,
  • C. Pont-Sunyer

      Affiliations

    • Neurology Department, Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    • ,
  • R. Vivanco

      Affiliations

    • Neurology Department, Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    • ,
  • G. Cucurella

      Affiliations

    • Neurology Department, Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    • ,
  • E. Giralt

      Affiliations

    • Neurology Department, Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    • ,
  • T. Delgado

      Affiliations

    • Neurology Department, Hospital de Sabadell-C.S. Parc Taulli, Sabadell, Spain
    • ,
  • C. Garcia

      Affiliations

    • Neurology Department, Hospital de Sabadell-C.S. Parc Taulli, Sabadell, Spain
    • ,
  • A. Seoane

      Affiliations

    • Gastroenterology Department, Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, Hospital del Mar, Barcelona, Spain
    • ,
  • R. Campo

      Affiliations

    • Gastroenterology Department, Hospital de Sabadell-C.S. Parc Taulli, Sabadell, Spain

Received 15 October 2008 ,Revised 17 May 2009 ,Accepted 29 July 2009.

References 

  1. Agid Y, Ahlshog E, Albanese A, Calne D, Chase T, De Yébenes J, et al. Levodopa in the treatment of Parkinson's disease: a consensus meeting. Mov Disord. 1995;14:911–913
  2. Marsden CD, Parkes JD, Quinn N. Fluctuations disability in Parkinson's disease-clinical aspects. In:  Masden CD,  Fahn S editor. Movement disorders. London: Butterworth; 1982;p. 96–122
  3. Tolosa E, Martin WE, Cohen HP, Jacobson RL. Patterns of clinical response and plasma dopa levels in Parkinson's disease. Neurology. 1975;25:177–183
  4. Kurlan R, Rothfield KP, Woodward WR, Nutt JG, Miller C, Lichter D, et al. Erratic gastric emptying may cause “random” fluctuations of parkinsonian mobility. Neurology. 1988;38:419–421
  5. Nyholm D, Askmark H, Gomes-Trolin C, Knutson T, Lennernäs H, Nyström C, et al. Optimizing levodopa pharmacokinetics: intestinal infusion versus oral sustained-release tablets. Clin Neuropharmacol. 2003;26:156–163
  6. Nyholm D, Nilsson Remahl, Dizdar N, Constantinescu R, Holmberg B, Jansson R, et al. Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease. Neurology. 2005;64:216–223
  7. Bredberg E, Nilsson D, Johansson K, Aquilonius SM, Johnels B, Nystrom C, et al. Intraduodenal infusion of a water-based levodopa dispersion for optimisation of the therapeutic effect in severe Parkinson's disease. Eur J Clin Pharmacol. 1993;45:117–122
  8. National Parkinson's Foundation. Hoehn and Yahr staging of Parkinson's disease, Unified Parkinson disease rating scale (UPDRS), and Schwab and England activities of daily living. Available at: http://www.parkinson.org/NETCOMMUNITY/Page.aspx?pid=367&srcid=202 [accessed 29.12.07].
  9. Department of Public Health, University of Oxford. PDP-39 Parkinson's disease questionnaire. Available at: http://www.publichealth.oxac.uk/units/hsru/PDQ.
  10. Schwab RS, England AC. Rn third symposium on Parkinson's disease. Edinburgh: E and S. Livingstone; 1969;p. 152–57
  11. Antonioni A, Isaias IU, Canesi M, Zibetti M, Manciani F, Manfredi L, et al. Duodenal levodopa infusión for advanced Parkinson's disease: 12-month treatment outcome. Mov Disord. 2007;22:1145–1149
  12. Kurth MC, Tetrud JW, Tanner CM, Irwin I, Stebbins GT, Goetz CG, et al. Double-blind, placebo-controlled, crossover study of duodenal infusion of levodopa/carbidopa in Parkinson's disease patients with “on–off” fluctuations. Neurology. 1993;43:1698–1703

☆ The review of this paper was entirely handled by an Associate Editor, Jonathan Carr.

PII: S1353-8020(09)00215-6

doi: 10.1016/j.parkreldis.2009.07.015

Parkinsonism & Related Disorders
Volume 16, Issue 3 , Pages 218-221 , March 2010

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