Parkinsonism & Related Disorders
Volume 16, Issue 3 , Pages 222-224 , March 2010

Genetic screening for mutations in the Nrdp1 gene in Parkinson disease patients in a Chinese population

  • Xiaoyun Mo

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • Experimental Center, The People’s Hospital of Guangxi Zhuang Autonomous Region, NanNing, Guangxi, China
    • These authors contributed equally to the study.
    • ,
  • Deyuan Liu

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • These authors contributed equally to the study.
    • ,
  • Wei Li

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • ,
  • Zhengmao Hu

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • ,
  • Yiqiao Hu

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • ,
  • Jingzhi Li

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • ,
  • Jifeng Guo

      Affiliations

    • Department of Neurology, Xiangya Hospital, Central South University, ChangSha, Hunan, China
    • ,
  • Beisha Tang

      Affiliations

    • Department of Neurology, Xiangya Hospital, Central South University, ChangSha, Hunan, China
    • ,
  • Zhuohua Zhang

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • ,
  • Yi Bai

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • Graduate school of Central South University, Central South University, ChangSha, Hunan, China
    • Corresponding Author InformationCorresponding authors at: State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, China. Tel.: +86 731 84805357.
    • ,
  • Kun Xia

      Affiliations

    • State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, Hunan 410078, China
    • School of Biological Science and Technology, Central South University, ChangSha, Hunan, China
    • Corresponding Author InformationCorresponding authors at: State Key Laboratory of Medical Genetics of China, Central South University, ChangSha, China. Tel.: +86 731 84805357.

Received 2 April 2009 ,Revised 31 August 2009 ,Accepted 2 September 2009.

References 

  1. Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM, et al. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A. 1999;96:11364–11369
  2. Qiu XB, Goldberg AL. Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proc Natl Acad Sci U S A. 2002;99:14843–14848
  3. Zhong L, Tan Y, Zhou A, Yu Q, Zhou J. RING finger ubiquitin-protein isopeptide ligase Nrdp1/FLRF regulates Parkin stability and activity. J Biol Chem. 2005;280:9425–9430
  4. Djarmati A, Hedrich K, Svetel M, Schafer N, Juric V, Vukosavic S, et al. Detection of Parkin (PARK2) and DJ1 (PARK7) mutations in early-onset Parkinson disease: Parkin mutation frequency depends on ethnic origin of patients. Hum Mutat. 2004;23:525
  5. Hattori N, Kitada T, Matsumine H, Asakawa S, Yamamura Y, Yoshino H, et al. Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the Parkin gene in affected individuals. Ann Neurol. 1998;44:935–941
  6. Periquet M, Latouche M, Lohmann E, Rawal N, De Michele G, Ricard S, et al. Parkin mutations are frequent in patients with isolated early-onset parkinsonism. Brain. 2003;126:1271–1278
  7. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell. 2001;105:891–902
  8. Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila Parkin mutants. Proc Natl Acad Sci U S A. 2003;100:4078–4083
  9. Yu F, Zhou J. Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress. Neurosci Lett. 2008;440:4–8
  10. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55:181–184
  11. Foroud T, Uniacke SK, Liu L, Pankratz N, Rudolph A, Halter C, et al. Heterozygosity for a mutation in the Parkin gene leads to later onset Parkinson disease. Neurology. 2003;60:796–801

☆ The review of this paper was entirely handled by an Associate Editor, En-King Tan.

PII: S1353-8020(09)00221-1

doi: 10.1016/j.parkreldis.2009.09.001

Parkinsonism & Related Disorders
Volume 16, Issue 3 , Pages 222-224 , March 2010

Article Tools