Parkinsonism & Related Disorders
Volume 16, Issue 3 , Pages 225-227 , March 2010

The effect of levodopa treatment on cerebral hemodynamics in patients with Parkinson's disease: Serial transcranial Doppler studies

  • Seok Woo Yong

      Affiliations

    • Department of Neurology, Ajou University School of Medicine, Suwon, South Korea
    • ,
  • Kyung Yul Lee

      Affiliations

    • Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea
    • ,
  • Phil Hyu Lee

      Affiliations

    • Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea
    • Corresponding Author InformationCorresponding author at: Department of Neurology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea. Tel.: +82 2 2228 1608; fax: +82 2 393 0705.

Received 14 May 2009 ,Revised 7 September 2009 ,Accepted 9 September 2009.

References 

  1. Diaz-Arrastia R. Homocysteine and neurologic disease. Arch Neurol. 2000;57:1422–1427
  2. Muller T, Renger K, Kuhn W. Levodopa-associated increase of homocysteine levels and sural axonal neurodegeneration. Arch Neurol. 2004;61:657–660
  3. Nakaso K, Yasui K, Kowa H, Kusumi M, Ueda K, Yoshimoto Y, et al. Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-DOPA, homocysteine, and MTHFR genotype. J Neurol Sci. 2003;207:19–23
  4. Rogers JD, Sanchez-Saffon A, Frol AB, Diaz-Arrastia R. Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease. Arch Neurol. 2003;60:59–64
  5. Mastaglia FL, Johnsen RD, Kakulas BA. Prevalence of stroke in Parkinson's disease: a postmortem study. Mov Disord. 2002;17:772–774
  6. Jellinger KA. Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study. Acta Neuropathol. 2003;105:415–419
  7. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55:181–184
  8. Lee KY, Sohn YH, Baik JS, Kim GW, Kim JS. Arterial pulsatility as an index of cerebral microangiopathy in diabetes. Stroke. 2000;31:1111–1115
  9. Legarth J, Nolsoe C. Doppler blood velocity waveforms and the relation to peripheral resistance in the brachial artery. J Ultrasound Med. 1990;9:449–453
  10. Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Bones C, Newcombe RG, et al. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 1998;98:1848–1852
  11. Rosengarten B, Osthaus S, Auch D, Kaps M. Effects of acute hyperhomocysteinemia on the neurovascular coupling mechanism in healthy young adults. Stroke. 2003;34:446–451
  12. Manrique J, Diaz A, Gavira JJ, Hernandez A, Pujante D, Errasti P. Preliminary results of the effect of treatment of hyperhomocysteinemia and its relationship with inflammation, coagulation status, and endothelial function after renal transplantation. Transpl Proc. 2005;37:3782–3784
  13. Vokatch N, Grotzsch H, Mermillod B, Burkhard PR, Sztajzel R. Is cerebral autoregulation impaired in Parkinson's disease? A transcranial doppler study. J Neurol Sci. 2007;254:49–53

☆ The review of this paper was entirely handled by an Associate Editor, En-King Tan.

PII: S1353-8020(09)00225-9

doi: 10.1016/j.parkreldis.2009.09.003

Parkinsonism & Related Disorders
Volume 16, Issue 3 , Pages 225-227 , March 2010

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