Parkinsonism & Related Disorders
Volume 16, Issue 4 , Pages 284-287 , May 2010

Association study of GATA-2 transcription factor gene (GATA2) polymorphism and Parkinson's disease

  • Mateusz Kurzawski

      Affiliations

    • Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland
    • Corresponding Author InformationCorresponding author. Tel./fax: +48 91 466 1600.
    • ,
  • Monika Białecka

      Affiliations

    • Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland
    • ,
  • Jarosław Sławek

      Affiliations

    • Department of Neurology, St Adalbert Hospital and Dept. of Neurological-Psychiatric Nursing, Medical University, Gdansk, Poland
    • ,
  • Gabriela Kłodowska-Duda

      Affiliations

    • ‘Neuro-Care’ Neurology Clinic, Katowice, Poland
    • ,
  • Marek Droździk

      Affiliations

    • Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland

Received 8 June 2009 ,Revised 29 September 2009 ,Accepted 12 October 2009.

References 

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  2. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature. 1997;388:839–840
  3. Farrer M, Kachergus J, Forno L, Lincoln S, Wang DS, Hulihan M, et al. Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann Neurol. 2004;55:174–179
  4. Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, et al. Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet. 2009;41:308–315
  5. Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, et al. GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci USA. 2008;105:10907–10912
  6. Nardelli J, Thiesson D, Fujiwara Y, Tsai FY, Orkin SH. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol. 1999;210:305–321
  7. Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, et al. GATA2 is associated with familial early-onset coronary artery disease. PLoS Genet. 2006;2:e139
  8. Daniel SE, Lees AJ. Parkinson's disease society brain bank, London: overview and research. J Neural Transm Suppl. 1993;39:165–172
  9. Hoehn MM, Yahr MD. Parkinsonism: onset, progression, and mortality. Neurology. 1967;17:427–442
  10. Zhao JH. 2LD, GENECOUNTING and HAP: computer programs for linkage disequilibrium analysis. Bioinformatics. 2004;20:1325–1326
  11. Pritchard JK, Przeworski M. Linkage disequilibrium in humans: models and data. Am J Hum Genet. 2001;69:1–14
  12. Nagai T, Harigae H, Ishihara H, Motohashi H, Minegishi N, Tsuchiya S, et al. Transcription factor GATA-2 is expressed in erythroid, early myeloid, and CD34þ human leukemia-derived cell lines. Blood. 1994;84:1074–1084

☆ The review of this paper was entirely handled by an Associate Editor, Vincenzo Bonifati.

PII: S1353-8020(09)00253-3

doi: 10.1016/j.parkreldis.2009.10.006

Parkinsonism & Related Disorders
Volume 16, Issue 4 , Pages 284-287 , May 2010

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