Abstract
This study reports a retrospective analysis of 16 patients to determine changes in
medication costs associated with deep brain stimulation of the bilateral subthalamic
nucleus (DBS B-STN). Antiparkinsonian medication (APMED) costs were evaluated pre-
and post-operatively at 1 and 2 years, based on prescribed dosages. After treatment
with DBS, patients experienced a 32% reduction in APMED costs after 1 year and a 39%
reduction after 2 years. Hypothetical projections of total potential savings are presented,
accounting for increasingly complex medication regimens and medication cost inflation.
DBS patients may experience a significant long-term reduction in the cost of their
pharmacologic treatment.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Parkinsonism & Related DisordersAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.N Engl J Med. 1998; 339: 1105-1111
- Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease.N Engl J Med. 2001; 345: 956-963
- Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson's disease.Lancet. 1997; 350: 1676
- Deep brain stimulation of the subthalamic nucleus: clinical effectiveness and safety.Neurology. 2001; 56: 552-554
- Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinson's disease and motor fluctuations.Mov Disord. 2002; 17: 693-700
- Bilateral subthalamic stimulation for Parkinson's disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance.J Neurosurg. 2000; 92: 615-625
- Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease.Neurology. 1998; 51: 850-855
- Bilateral deep brain stimulation of the subthalamic nucleus in Parkinson's disease.Neurology. 2000; 55: S45-S51
- Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy.J Neurol. 2001; 248: III/37, III/47
- Levodopa withdrawal after bilateral subthalamic nucleus stimulation in advanced Parkinson disease.Arch Neurol. 2000; 57: 983-988
- Deep brain stimulation of the subthalamic nucleus for control of extrapyramidal features in advanced idiopathic Parkinson's disease: one year follow-up.J Neural Transm. 1999; 106: 693-709
- Apomorphine test: a predictor for motor responsiveness to deep brain stimulation of the subthalamic nucleus.J Neurol. 1999; 246: 907-913
- Evaluation of healthcare utilization and health status of patients with Parkinson's disease treated with deep brain stimulation of the subthalamic nucleus.J Neurol. 2002; 249: 759-766
- Deep brain stimulation in the treatment of Parkinson's disease: a cost-effectiveness analysis.Neurology. 2001; 57: 663-671
- Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson's disease.Neurology. 1999; 53: 85-90
- Subthalamic nucleus stimulation in Parkinson's disease: clinical evaluation of 18 patients.J Neurol. 2002; 249: 529-534
- Subthalamic stimulation in Parkinson disease.Arch Neurol. 2000; 57: 461-465
- Subthalamic DBS replaces levodopa in Parkinson's disease: two-year follow-up.Neurology. 2002; 58: 396-401
- Deep brain stimulation of the subthalamic nucleus for Parkinson's disease: methodologic aspects and clinical criteria.Neurology. 2000; 55: S40-S44
- Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: long term follow-up.Neurol Sci. 2002; 23: S111-S112
- Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson's disease.Brain. 1998; 121: 451-457
- Bilateral stimulation of the subthalamic nucleus in patients with Parkinson disease: a study of efficacy and safety.J Neurosurg. 2002; 96: 666-672
- Implantation of deep brain stimulators into the subthalamic nucleus: technical approach and magnetic resonance imaging-verified lead locations.J Neurosurg. 2002; 97: 370-387
- Methods for microelectrode-guided posteroventral pallidotomy.J Neurosurg. 1996; 84: 194-202
- Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease.Ann Neurol. 1998; 44: 622-628
- Microelectrode-guided pallidotomy: technical approach and its application in medically intractable Parkinson's disease.J Neurosurg. 1998; 88: 1027-1043
- Drug topics red book. Medical Economics Co, Montvale, NJ2002
- Motor response to levodopa and the evolution of motor fluctuations in the first decade of treatment of Parkinson's disease.Mov Disord. 2002; 17: 1227-1234
- Differential progression of motor impairment in levodopa-treated Parkinson's disease.Mov Disord. 2000; 15: 479-484
- Evolution of motor fluctuations in Parkinson's disease: a longitudinal study over 6 years.Mov Disord. 1999; 14: 605-611
- Limitations of current Parkinson's disease therapy.Ann Neurol. 2003; 53: S3-S15
Article info
Publication history
Accepted:
May 20,
2004
Received in revised form:
May 15,
2004
Received:
February 23,
2004
Identification
Copyright
© 2004 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
