Abstract
We tested the hypothesis that mood, clinical manifestations and cognitive impairment
of levodopa-treated Parkinson's disease (PD) patients are associated with vitamin
B12 and folate deficiency. To this end, we performed this cross-sectional study by
measuring serum folate and vitamin B12 blood levels in 111 consecutive PD patients.
Levodopa-treated PD patients showed significantly lower serum levels of folate and
vitamin B12 than neurological controls, while depressed patients had significantly
lower serum folate levels as compared to non-depressed.
Cognitively impaired PD patients exhibited significantly lower serum vitamin B12 levels
as compared to cognitively non-impaired. In conclusion, lower folate levels were associated
with depression, while lower vitamin B12 levels were associated with cognitive impairment.
The effects of vitamin supplementation merit further attention and investigation.
Keywords
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Article info
Publication history
Accepted:
October 1,
2007
Received in revised form:
August 21,
2007
Received:
March 3,
2006
Identification
Copyright
© 2007 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
