Abstract
This systematic review critically evaluates the literature to identify the demographic
and clinical factors that predict the health-related quality of life (HRQOL) of people
with Parkinson’s disease (PD). Understanding how these factors relate to HRQOL in
people with PD may assist clinicians minimise the functional and social impact of
the disease by optimising their assessment and clinical decision making processes.
A tailored search strategy in six databases identified 29 full-text reports that fulfilled
the pre-defined inclusion and exclusion criteria. The quality of included studies
was assessed by two independent reviewers using a customised assessment form. A best-evidence
synthesis was used to summarise the demographic and clinical factors that were examined
in relation to HRQOL. Depression was the most frequently identified determinant of
HRQOL in people with idiopathic PD. Disease severity and disease disability were also
found to be predictive of poor HRQOL outcomes in many studies. The motor symptoms
that contributed most often to overall life quality were gait impairments and complications
arising from medication therapy. To minimise the impact of PD on HRQOL, it may be
necessary to consider the extent to which demographic factors and motor and non-motor
symptoms contribute to life quality.
Keywords
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References
- The World Health Organization quality of life assessment (WHOQOL): position paper from the World Health Organization.Soc Sci Med. 1995; 41: 1403-1409
- Assessing quality of life in clinical research: from where have we come and where are we going?.J Clin Epidemiol. 1999; 52: 355-363
- Quality of life and related concepts in Parkinson’s disease: a systematic review.Mov Disord. 2007; 22: 1528-1537
- Prognostic factors for the progression of Parkinson’s disease: a systematic review.Mov Disord. 2007; 22: 1839-1851
- The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies.Ann Intern Med. 2007; 147: 573-577
- Meta-analysis of observational studies in epidemiology – a proposal for reporting.JAMA. 2000; 283: 2008-2012
- Quantification of soft tissue artifact in lower limb human motion analysis: a systematic review.Gait Posture. 2010; 31: 1-8
- Evaluating non-randomised intervention studies.Health Technol Assess. 2003; 7 (1–173): iii-x
- Evaluation of the quality of prognosis studies in systematic reviews.Ann Intern Med. 2006; 144: 427-437
- Cochrane handbook for systematic reviews of interventions.([Updated 2008; cited version 5.0.1]. Available from)2008
- Factors impacting on quality of life in Parkinson’s disease: results from an international survey.Mov Disord. 2002; 17: 60-67
- Impact of social functioning and vitality on preference for life in patients with Parkinson’s disease.Mov Disord. 2003; 18: 171-175
- Health related quality of life in early Parkinson’s disease: impact of motor and non-motor symptoms, results from Chinese levodopa exposed cohort.Parkinsonism Relat Disord. 2009; 15: 767-771
- Depressive symptoms impacting on health-related quality of life in early Parkinson’s disease: results from Chinese L-dopa exposed cohort.Clin Neurol Neurosurg. 2009; 111: 733-737
- The health burdens of Parkinson’s disease.Mov Disord. 1998; 13: 406-413
- Linking clinical variables to health-related quality of life in Parkinson’s disease.Parkinsonism Relat Disord. 2002; 8: 199-209
- Influence of motor symptoms upon the quality of life of patients with Parkinson’s disease.Eur Neurol. 2007; 57: 161-165
- Association of rural life setting and poorer quality of life in Parkinson’s disease patients: a cross-sectional study in Croatia.Eur J Neurol. 2007; 14: 194-198
- Determinants of disability and quality of life in mild to moderate Parkinson disease.Neurology. 2008; 70: 2241-2247
- What contributes to quality of life in patients with Parkinson’s disease?.J Neurol Neurosurg Psychiatry. 2000; 69: 308-312
- Factors affecting health-related quality of life amongst Asian patients with Parkinson’s disease.Eur J Neurol. 2008; 15: 737-742
- Social and clinical determinants of quality of life in Parkinson’s disease in Austria: a cohort study.J Neurol. 2010; 257: 638-645
- Social and clinical determinants of quality of life in Parkinson’s disease in a Russian cohort study.Parkinsonism Relat Disord. 2010; 16: 243-248
- Determinants of quality of life in Brazilian patients with Parkinson’s disease.Mov Disord. 2007; 22: 1408-1415
- The influence of fatigue on health-related quality of life in patients with Parkinson’s disease.Acta Neurol Scand. 2003; 107: 1-6
- Quality of life measurements in patients with Parkinson’s disease: a community-based study.Eur J Neurol. 1998; 5: 443-450
- Influence of clinical and demographic variables on quality of life in patients with Parkinson’s disease.J Neurol Neurosurg Psychiatry. 1999; 66: 431-435
- Falls in Parkinson’s disease. Causes and impact on patients’ quality of life.Funct Neurol. 2005; 20: 163-168
- Anxiety and depression: main determinants of health-related quality of life in Brazilian patients with Parkinson’s disease.Parkinsonism Relat Disord. 2008; 14: 102-108
- The importance of educational and psychological factors in Parkinson’s disease quality of life.Eur J Neurol. 2002; 9: 589-593
- Factors affecting the quality of life of patients with idiopathic Parkinson’s disease – a cross-sectional study in an outpatient clinic attendees.Parkinsonism Relat Disord. 2005; 11: 465-468
- Parkinsonism – onset, progression and mortality.Neurology. 1967; 17: 427-442
- Quality of life in Parkinson’s disease: the relative importance of the symptoms.Mov Disord. 2008; 23: 1428-1434
- Measuring quality of life in Parkinson’s disease: selection of an appropriate health-related quality of life instrument.Physiotherapy. 2010; (doi:10.1016/j.physio.2010.05.006)
- Impact of the motor complications of Parkinson’s disease on the quality of life.Mov Disord. 2005; 20: 224-230
- Effects of respiratory muscle weakness on daily living function, quality of life, activity levels, and exercise capacity in mild to Parkinson’s disease.Am J Phys Med Rehabil. 2004; 83: 601-607
- A comparison of Parkinson’s disease symptoms and self-reported functioning and well being.Parkinsonism Relat Disord. 1997; 3: 207-209
- A profile of neuropsychiatric problems and their relationship to quality of life for Parkinson’s disease patients without dementia.Parkinsonism Relat Disord. 2008; 14: 37-42
- Quality of life in Polish patients with long-lasting Parkinson’s disease.Mov Disord. 2004; 19: 667-672
- Quality of life in patients with Parkinson’s disease.Parkinsonism Relat Disord. 2005; 11: 221-226
- Quality of life in Parkinson’s disease: Indian scenario.J Assoc Physicians India. 2006; 54: 17-21
- Best evidence synthesis: an intelligent alternative to meta-analysis.J Clin Epidemiol. 1995; 48: 9-18
- UPDRS Development Committee. Unified Parkinson’s disease rating scale.in: Fahn S. Recent developments in Parkinson’s disease. Macmillan, New York1987: 153-163
- Quality of life and depression in Parkinson’s disease.J Neurol Sci. 2006; 248: 151-157
- Metric attributes of the unified Parkinson’s disease rating scale 3.0 battery: part II, construct and content validity.Mov Disord. 2006; 21: 1892-1898
- Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations.Mov Disord. 2004; 19: 1020-1028
- Projection technique for evaluating surgery in Parkinson’s disease.in: Gillingham F.J. Donaldson I.M.L. Fraser J. Hitchcock E. Jellinke E. Smythies J. Third symposium on Parkinson’s disease. E&S Livingstone Ltd, London1968: 152-157
- Utility of an objective dyskinesia rating scale for Parkinson’s disease: interrater and intrarater reliability assessment.Mov Disord. 1994; 9: 390-394
Biography
Ms Sze-Ee Soh is a Physiotherapist and a PhD student at the Melbourne School of Health Sciences in The University of Melbourne.
Biography
Professor Meg E. Morris is a Professor of Physiotherapy, Associate Dean and Head of the Melbourne School of Health Sciences at The University of Melbourne.
Biography
Dr Jennifer McGinley is a Physiotherapist, Group Leader of Gait Analysis Research at the Murdoch Childrens Research Institute and Senior Research Fellow at the Melbourne School of Health Sciences in The University of Melbourne.
Article info
Publication history
Accepted:
August 13,
2010
Received in revised form:
August 12,
2010
Received:
July 2,
2010
Footnotes
☆The review of this paper was entirely handled by the Co-Editor-in-Chief, Prof. Z.K. Wszolek.
Identification
Copyright
© 2010 Published by Elsevier Inc. All rights reserved.
