Advertisement

Parkinsonism after chronic occupational exposure to glyphosate

  • Gang Wang
    Affiliations
    Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Search for articles by this author
  • Xiao-Ning Fan
    Affiliations
    Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Search for articles by this author
  • Yu-Yan Tan
    Affiliations
    Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Search for articles by this author
  • Qi Cheng
    Affiliations
    Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Search for articles by this author
  • Sheng-Di Chen
    Correspondence
    Corresponding author. Tel./fax: +86 21 64454473.
    Affiliations
    Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Search for articles by this author
      As a broad-spectrum herbicide employed to kill weeds, glyphosate (N-(phosphonomethyl) glycine) is typically either sprayed to be absorbed through the leaves, injected into the trunk, or applied to the stump of a tree, and is also used to control vegetation around transmission towers, pipelines, water drainage channels, public squares, and streets throughout the world [
      • Bradberry S.M.
      • Proudfoot A.T.
      • Vale J.A.
      Glyphosate poisoning.
      ]. In China, glyphosate is popularly used as a hypotoxic weed-killer in rural areas. Every year, there are reports of acute intoxication of glyphosate due to attempted suicide or error in usage among adults and children [
      • Xu M.Z.
      • Liu Q.Y.
      • Long J.X.
      • Ren J.Y.
      Acute intoxication of glyphosate: 13 case reports.
      ]. Symptoms in such cases are frequently reported as consisting of digestive tract dysfunction, circulatory and respiratory failure, and liver and kidney damage [
      • Bradberry S.M.
      • Proudfoot A.T.
      • Vale J.A.
      Glyphosate poisoning.
      ,
      • Xu M.Z.
      • Liu Q.Y.
      • Long J.X.
      • Ren J.Y.
      Acute intoxication of glyphosate: 13 case reports.
      ]. Neurological involvement, in particular extrapyramidal symptoms and signs including limb rigidity and resting tremor, has only been reported following a few isolated events rather than in the setting of chronic occupational exposure [
      • Barbosa E.R.
      • Leiros da Costa M.D.
      • Bacheschi L.A.
      • Scaff M.
      • Leite C.C.
      Parkinsonism after glycine-derivate exposure.
      ].
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Parkinsonism & Related Disorders
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bradberry S.M.
        • Proudfoot A.T.
        • Vale J.A.
        Glyphosate poisoning.
        Toxicol Rev. 2004; 23: 159-167
        • Xu M.Z.
        • Liu Q.Y.
        • Long J.X.
        • Ren J.Y.
        Acute intoxication of glyphosate: 13 case reports.
        Chin J Crit Care Med (Electronic Edition). 2009; 2: 39-40
        • Barbosa E.R.
        • Leiros da Costa M.D.
        • Bacheschi L.A.
        • Scaff M.
        • Leite C.C.
        Parkinsonism after glycine-derivate exposure.
        Mov Disord. 2001; 16: 565-568
        • Lajmanovich R.C.
        • Attademo A.M.
        • Peltzer P.M.
        • Junges C.M.
        • Cabagna M.C.
        Toxicity of four herbicide formulations with glyphosate on Rhinella arenarum (Anura: Bufonidae) tadpoles: B-esterases and glutathione S-transferase inhibitors.
        Arch Environ Contam Toxicol. 2010 Jul 29; ([Epub ahead of print])
        • Malhotra R.C.
        • Ghia D.K.
        • Cordato D.J.
        • Beran R.G.
        Glyphosate-surfactant herbicide-induced reversible encephalopathy.
        J Clin Neurosci. 2010; 17: 1472-1473