Highlights
- •We investigated concomitant DJ and ICDs in PD.
- •We found preliminary evidence of an association between DJ and hypersexuality.
- •DJ and hypersexuality may reflect a common alteration of sexuality.
- •Sexuality should be investigated when features of either one of them appear.
Abstract
Background
Both impulse-control disorders and delusional jealousy (DJ) may be considered non-motor
side-effects of dopamine agonist therapy in Parkinson's disease (PD). We aimed to
investigate the possible concomitant development of these features in PD and their
clinical correlates.
Methods
We performed a cross-sectional investigation in 1063 consecutive PD patients with
the Questionnaire for Impulsive Compulsive Disorders in Parkinson's disease and the
Parkinson's Psychosis Questionnaire.
Results
81 patients presented ICDs (prevalence 7.61%) and 23 patients presented DJ (17 males,
6 females; prevalence 2.16%). 9 male PD patients presented both DJ and ICDs (39.13%
of patients with DJ, 11.11% of patients with ICDs; prevalence of 0.84% in the whole
PD sample), with a concomitant onset of delusional jealousy and hypersexuality in
8 cases and a concomitant onset of delusional jealousy and pathological gambling in
2 cases.
Discussion
Hypersexuality and delusional jealousy may occur independently in PD patients “on”
dopamine agonist therapy, but may develop together probably reflecting a common alteration
of sexuality (sexual arousal and jealousy) The presence of both of these clinical
features and sexuality more in general should be investigated when features of either
one of them appear. Further confirmation is needed in larger samples of patients.
Keywords
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Article info
Publication history
Published online: September 18, 2014
Accepted:
September 10,
2014
Received in revised form:
August 4,
2014
Received:
June 11,
2014
Identification
Copyright
© 2014 Published by Elsevier Inc.
