- •We investigated concomitant DJ and ICDs in PD.
- •We found preliminary evidence of an association between DJ and hypersexuality.
- •DJ and hypersexuality may reflect a common alteration of sexuality.
- •Sexuality should be investigated when features of either one of them appear.
Both impulse-control disorders and delusional jealousy (DJ) may be considered non-motor side-effects of dopamine agonist therapy in Parkinson's disease (PD). We aimed to investigate the possible concomitant development of these features in PD and their clinical correlates.
We performed a cross-sectional investigation in 1063 consecutive PD patients with the Questionnaire for Impulsive Compulsive Disorders in Parkinson's disease and the Parkinson's Psychosis Questionnaire.
81 patients presented ICDs (prevalence 7.61%) and 23 patients presented DJ (17 males, 6 females; prevalence 2.16%). 9 male PD patients presented both DJ and ICDs (39.13% of patients with DJ, 11.11% of patients with ICDs; prevalence of 0.84% in the whole PD sample), with a concomitant onset of delusional jealousy and hypersexuality in 8 cases and a concomitant onset of delusional jealousy and pathological gambling in 2 cases.
Hypersexuality and delusional jealousy may occur independently in PD patients “on” dopamine agonist therapy, but may develop together probably reflecting a common alteration of sexuality (sexual arousal and jealousy) The presence of both of these clinical features and sexuality more in general should be investigated when features of either one of them appear. Further confirmation is needed in larger samples of patients.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Parkinsonism & Related Disorders
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- A single-center, cross-sectional prevalence study of impulse control disorders in Parkinson disease: association with dopaminergic drugs.J Clin Psychopharmacol. 2013; 33: 691-694
- Dopamine agonists and delusional jealousy in Parkinson's disease: a cross-sectional prevalence study.Mov Disord. 2012; 27: 1679-1682
- Acute and chronic cognitive effects of levodopa and dopamine agonists in patients with Parkinson's disease: a review.Ther Adv Psychopharmacol. 2013; 3: 101-113
- Prefrontal cortex, dopamine and jealousy endophenotype.CNS Spectr. 2013; 18: 6-14
- Diagnostic and statistical manual for mental disorders.(text revision (DSM-IV-TR))4th ed. American Psychiatric Association, Washington, DC2000
- Validation of the questionnaire for impulsive compulsive disorders in Parkinson's disease (QUIP).Mov Disord. 2009; 24: 1461-1467
- Development and evaluation of the Parkinson's psychosis questionnaire. A screening-instrument for the early diagnosis of drug-induced psychosis in Parkinson's disease.J Neurol. 2005; 252: 1060-1066
- Impulse control disorders in Parkinson's disease: a cross-sectional study of 3090 patients.Arch Neurol. 2010; 67: 589-595
- Neural response to visual sexual cues in dopaminergic treatment-linked hypersexuality in Parkinson's disease.Brain. 2013; 136: 400-411
- Dopamine agonists and delusional jealousy in Parkinson's disease: a cross-sectional prevalence study.Mov Disord. 2013; 25: 689
- Delusional jealousy in Parkinson's disease patients with and without dementia.Neurol Sci. 2014; 35: 1307-1308
- The common neural bases between sexual desire and love: a multilevel kernel density fMRI analysis.J Sex Med. 2012; 9: 1048-1054
- Exploring hypersexual behavior in men with Parkinson's disease: is it compulsive behavior?.J Parkinsons Dis. 2012; 2: 225-234
Published online: September 18, 2014
Accepted: September 10, 2014
Received in revised form: August 4, 2014
Received: June 11, 2014
© 2014 Published by Elsevier Inc.