Objectives: Canonical Wnt/βcatenin signaling chiefly regulates dopaminergic (DA) neurodevelopment, hippocampal neurogenesis and synaptic plasticity. We have provided substantial evidence that timely activation of endogenous Wnt/β-catenin signaling within and outside the neurogenic niches promotes an intrinsic compensatory program leading to histopathological and functional nigrostriatal DA neurorepair in the MPTP model of Parkinson's disease (PD) (1-3). Here, we investigated the response of the hippocampal dentate gyrus (DG) where the disruption of the DA balance in the hippocampus inhibits neurogenesis in and this may be crucial for the clinical neurological and cognitive deficits observed in PD.
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© 2015 Published by Elsevier Inc.