Abstract| Volume 22, SUPPLEMENT 2, e183-e184, January 2016

Nigrostriatal degeneration dictates a top-down genetic program for neuroplasticity and neurorepair: Focus on the hippocampus and Wnt/GSK-3β/β-catenin signaling cascade

      Objectives: Canonical Wnt/βcatenin signaling chiefly regulates dopaminergic (DA) neurodevelopment, hippocampal neurogenesis and synaptic plasticity. We have provided substantial evidence that timely activation of endogenous Wnt/β-catenin signaling within and outside the neurogenic niches promotes an intrinsic compensatory program leading to histopathological and functional nigrostriatal DA neurorepair in the MPTP model of Parkinson's disease (PD) (1-3). Here, we investigated the response of the hippocampal dentate gyrus (DG) where the disruption of the DA balance in the hippocampus inhibits neurogenesis in and this may be crucial for the clinical neurological and cognitive deficits observed in PD.
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