Highlights
- •Body composition investigated by MRI showed no alteration in total body fat in PD.
- •PD patients showed a higher visceral to subcutaneous fat ratio compared to controls.
- •Weight loss in PD was associated with increased visceral to subcutaneous fat ratio.
- •Fat distribution in PD patients was worsened by weight loss during disease progression.
Abstract
Introduction
There is some evidence that Parkinson's Disease (PD) patients have lower body weight
and lower fat mass when compared to healthy subjects and that lower body weight and
fat mass influence disease risk and progression. It remains unclear, however, if weight
loss of fat mass loss occurs only in a subgroup of patients and whether fat distribution
is altered during PD. The aim of this study was to prospectively investigate adipose
tissue content and distribution in PD patients.
Methods
The body fat composition of PD patients (N = 54) was compared with age matched healthy
controls (N = 55) using a magnetic resonance imaging (MRI)-based method. A longitudinal
MRI scan was acquired in 25 PD patients after a mean follow up period of 12 months.
Results
The volume of total body fat as well as of visceral fat showed no difference between
PD patients and healthy controls at baseline or at follow up. However, PD patients
displayed decreased subcutaneous fat tissue (p = 0.01) and a higher visceral to subcutaneous
fat ratio as compared to controls (p = 0.004). After follow up, 16 PD patients did
not lose weight, while 9 PD patients lost between 0.5 and 10 kg.
Conclusion
Fat distribution is altered in PD patients, with an increased ratio of visceral to
subcutaneous fat.
Keywords
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Article info
Publication history
Published online: September 16, 2016
Accepted:
September 15,
2016
Received in revised form:
August 22,
2016
Received:
May 8,
2016
Identification
Copyright
© 2016 Elsevier Ltd. All rights reserved.
