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Review article| Volume 40, P11-17, July 2017

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Parkinson's disease and pregnancy: An updated review

  • Mara Seier
    Correspondence
    Corresponding author. Northwest Parkinson Disease Research Education and Clinical Center, Portland VA Medical Center, PO Box 1034, Portland, OR, USA.
    Affiliations
    Northwest Parkinson Disease Research Education and Clinical Center, Portland VA Medical Center, Portland, OR, USA

    Department of Neurology, Oregon Health Sciences University, Portland, OR, USA
    Search for articles by this author
  • Amie Hiller
    Affiliations
    Northwest Parkinson Disease Research Education and Clinical Center, Portland VA Medical Center, Portland, OR, USA

    Department of Neurology, Oregon Health Sciences University, Portland, OR, USA
    Search for articles by this author

      Highlights

      • About half of women experience worsening of PD symptoms during pregnancy.
      • Use of anti-PD medications reduces worsening of symptoms to only a third of patients.
      • Women with PD do not have higher rates of birth or fetal complications.
      • Levodopa has the most use and safety data to recommend its use during pregnancy.
      • Amantadine should be avoided in women trying to conceive or those who become pregnant.

      Abstract

      Pregnancy does not often occur in the setting of Parkinson's disease (PD) as the most common age of onset is beyond the childbearing years, yet management of these two conditions is crucial for the health of both mother and child. Here we review treatment data of PD during pregnancy, primarily from case reports and drug registries, and focus on available evidence regarding the pregnancy risks for patient and fetus. Historically, it was reported that many women had worsening of symptoms during pregnancy but this may be because anti-parkinsonian medications were not recommended or were under dosed. Levodopa has the best safety data for use in pregnancy and amantadine should be avoided in women who are pregnant or trying to become pregnant. The data for other pharmacological and surgical treatments is less clear. There is no evidence that women with PD have higher rates of birth or fetal complications.

      Keywords

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