Highlights
- •About half of women experience worsening of PD symptoms during pregnancy.
- •Use of anti-PD medications reduces worsening of symptoms to only a third of patients.
- •Women with PD do not have higher rates of birth or fetal complications.
- •Levodopa has the most use and safety data to recommend its use during pregnancy.
- •Amantadine should be avoided in women trying to conceive or those who become pregnant.
Abstract
Pregnancy does not often occur in the setting of Parkinson's disease (PD) as the most
common age of onset is beyond the childbearing years, yet management of these two
conditions is crucial for the health of both mother and child. Here we review treatment
data of PD during pregnancy, primarily from case reports and drug registries, and
focus on available evidence regarding the pregnancy risks for patient and fetus. Historically,
it was reported that many women had worsening of symptoms during pregnancy but this
may be because anti-parkinsonian medications were not recommended or were under dosed.
Levodopa has the best safety data for use in pregnancy and amantadine should be avoided
in women who are pregnant or trying to become pregnant. The data for other pharmacological
and surgical treatments is less clear. There is no evidence that women with PD have
higher rates of birth or fetal complications.
Keywords
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Article info
Publication history
Published online: May 11, 2017
Accepted:
May 10,
2017
Received in revised form:
May 10,
2017
Received:
March 3,
2017
Identification
Copyright
Published by Elsevier Ltd.