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The overlap between Essential tremor and Parkinson disease

  • Musleh Algarni
    Affiliations
    Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
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  • Alfonso Fasano
    Correspondence
    Corresponding author. University of Toronto, Krembil Research Institute, Toronto, Ontario, Canada, Movement Disorders Centre - Toronto Western Hospital, 399 Bathurst St, 7MacL412, Toronto, ON M5T 2S8, Canada.
    Affiliations
    Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada

    Krembil Research Institute, Toronto, Ontario, Canada
    Search for articles by this author

      Abstract

      Introduction

      Essential tremor (ET) and Parkinson's disease (PD) are common disorders especially in the aging population and can have overlapping features that can make it difficult to differentiate between the two. In addition, a possible overlap from a pathophysiological standpoint has been often advocated in the past.

      Methods

      In this review article, we gather the recent evidence in favor or against a possible relationship between ET and PD. This exercise follows the new advances in the field of tremor from both a pathophysiological and nosological perspective.

      Results

      Dividing ET patients into early onset and late onset disease subtypes can prove useful in ascertaining the phenotypic, epidemiological and genetic characteristics defining its relationships to PD. The only way to ascertain whether ET increases the risk of future PD would be to conduct a longitudinal cohort study on early-onset ET patients. On the other hand, ET-plus patients or late-onset cases with ET of short-duration might represent a group of PD patients in their pre-diagnostic phase after the pre-motor stage.

      Conclusion

      In spite of the growing body of literature in recent years of an overlap between ET and PD, we are far from elucidating the relationship (if any) between these two common disorders.

      Keywords

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