Highlights
- •Parkinson's disease (PD) is characterized by motor and non-motor symptoms (NMS).
- •Motor and NMS may impact negatively on Health-related quality of life (HRQoL).
- •Reduced HRQoL was associated with poorer cognitive performance.
- •Reduced HRQoL was associated with more severe depression, apathy and anxiety in PD.
- •Reduced functional autonomy, high anxiety and apathy contributed to reduce HRQoL in PD.
Abstract
Introduction
Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms
that may impact negatively on the activities of the patient's daily life and reduce
Health-related quality of life (HRQoL). The present study explored the impact of specific
non-motor symptoms on the HRQoL in PD.
Methods
Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing
global functioning and several questionnaires to assess depression, apathy, impulse
control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment.
The perceived QoL was assessed by Parkinson's Disease Questionnaire (PDQ-8).
The PD sample was divided into patients with high and low HRQoL around the median
of PDQ-8 and compared on clinical features, cognitive and neuropsychiatric variables.
A linear regression analysis, in which the global functioning, apathy, depression,
anxiety, anhedonia, ICD and the functional autonomy scores were entered as independent
variables and PDQ-8 score as dependent variable, was applied.
Results
Patients with lower HRQoL were more depressed, apathetic, anxious and showed more
severe reduction of functional autonomy and global functioning than patients with
high HRQoL. The regression analysis revealed that higher level of anxiety, executive
apathy and more reduced functional autonomy were significantly associated with higher
score on PDQ-8.
Conclusions
The finding indicated that anxiety, apathy associated with impaired planning, attention
and organization (i.e., executive apathy evaluated by the Dimensional Apathy Scale)
and reduced functional autonomy contribute significantly to reduce the HRQoL in PD.
Therefore, early identification and management of these neuropsychiatric symptoms
should be relevant to preserve HRQoL in PD.
Keywords
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Article info
Publication history
Published online: August 04, 2017
Accepted:
August 2,
2017
Received in revised form:
July 31,
2017
Received:
April 27,
2017
Identification
Copyright
© 2017 Elsevier Ltd. All rights reserved.
