Objective: In addition to dopaminergic neurons, the brain contains so-called “monoenzymatic”
neu- rons that express one of the enzymes of dopamine (DA) synthesis, tyrosine hydroxylase
(TH) or aromatic L-amino acid decarboxylase (AADC). The number of monoenzymatic neurons
in the striatum increases sig- nificantly in parkinsonian animals and patients with
Parkinson’s disease, but nothing is known about their functional significance. Therefore,
the objective of this study was to test our hypothesis that the striatal monoenzymatic
neurons produce DA in cooperation, and this is a compensatory reaction under a failure
of the nigrostriatal dopaminergic system.
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© 2017 Published by Elsevier Inc.
