Objective: In addition to dopaminergic neurons, the brain contains so-called “monoenzymatic” neu- rons that express one of the enzymes of dopamine (DA) synthesis, tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC). The number of monoenzymatic neurons in the striatum increases sig- nificantly in parkinsonian animals and patients with Parkinson’s disease, but nothing is known about their functional significance. Therefore, the objective of this study was to test our hypothesis that the striatal monoenzymatic neurons produce DA in cooperation, and this is a compensatory reaction under a failure of the nigrostriatal dopaminergic system.
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