Abstract| Volume 46, SUPPLEMENT 2, e26-e27, January 2018

Cooperative synthesis of dopamine by striatal non-dopaminergic neurons as a mechanism of neuroplasticity at parkinsonism

      Objective: In addition to dopaminergic neurons, the brain contains so-called “monoenzymatic” neu- rons that express one of the enzymes of dopamine (DA) synthesis, tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC). The number of monoenzymatic neurons in the striatum increases sig- nificantly in parkinsonian animals and patients with Parkinson’s disease, but nothing is known about their functional significance. Therefore, the objective of this study was to test our hypothesis that the striatal monoenzymatic neurons produce DA in cooperation, and this is a compensatory reaction under a failure of the nigrostriatal dopaminergic system.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Parkinsonism & Related Disorders
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect