Objective: Parkinson’s disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. The objective of our work was to study molecular mechanisms of neurodegeneration and neuroplasticity in the nigrostriatal system at modeling preclinical and clinical stages of PD that would serve to develop preclinical diagnosis and preventive therapy.
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© 2017 Published by Elsevier Inc.