Highlights
- •Extensive overview of prevalence and incidence of all types of parkinsonism.
- •Among parkinsonism, 80% of patients present with degenerative parkinsonism.
- •Among degenerative parkinsonism, patients present with PD in 81% of cases.
- •First Swiss population-based epidemiological study on Parkinson's disease and parkinsonism.
- •Swiss estimates appear similar to that observed in most European countries.
Abstract
Objectives
A large descriptive cross-sectional population-based prevalence study as well as a
retrospective incidence study were undertaken to ascertain the frequency of Parkinson's
Disease (PD) and other types of degenerative and non-degenerative parkinsonism in
the Canton of Geneva, Switzerland.
Methods
An extensive case-finding approach including records from public hospitals, private
neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism
established between 2003 and 2012 were included. Diagnosis of parkinsonism was ascertained
by a movement disorders specialist, based on published and validated consensus diagnostic
criteria.
Results
A total of 1235 living patients with parkinsonism were identified, from which 80%
presented with a degenerative form and 20% with a non-degenerative form of parkinsonism.
Among the former, PD was the most frequent diagnosis (81%, age-adjusted prevalence:
183/105 inhabitants, age-adjusted average annual incidence: 20/105/year) followed by dementia with Lewy bodies (9%), progressive supranuclear palsy
(3.9%), multisystem atrophy (1.9%) and corticobasal syndrome (1.4%). Among non-degenerative
parkinsonism, drug-induced parkinsonism was the most frequent diagnosis (43.4%), followed
by vascular parkinsonism (37%), normal pressure hydrocephalus (5.1%) and parkinsonism
in the context of a psychiatric disorder or functional parkinsonism (3.8%). Crude,
age-, sex-specific and age-adjusted prevalence and incidence of all types of parkinsonism
are detailed for each diagnosis.
Conclusion
This is the first Swiss population-based epidemiological study of PD and parkinsonism.
It provides an extensive overview of the prevalence and incidence of degenerative
and non-degenerative forms of parkinsonism. These data may assist clinicians with
their clinical workup.
Keywords
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Article info
Publication history
Published online: April 09, 2018
Accepted:
March 29,
2018
Received in revised form:
February 12,
2018
Received:
October 23,
2017
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
