Highlights
- •Comparison of retinal morphology in Parkinson’s disease, glaucoma and healthy controls using OCT retinal imaging.
- •Imaging of macular retinal layers did not reveal changes in macular inner retinal thickness in PD patients.
- •IpRNFL of the ipsilateral eye to the most-affected body side with bradykinesia was slightly thinner in PD patients.
- •Macular inner retinal thickness and pRNFL measurement did not prove to be a diagnostic biomarker of neurodegeneration in PD.
Abstract
Background
The topic of retinal neurodegeneration in PD is controversial, therefore the objective
was to compare macular ganglion cell complex (mGCC) and peripapillary retinal nerve
fiber layer (pRNFL) thickness in PD using 2 Spectral-Domain (SD) Optical Coherence
Tomography (OCT) devices.
Methods
In total, 146 eyes of 130 age-similar patients were included, of these 46 eyes of
30 PD patients, 60 eyes of 60 glaucoma patients and 40 eyes of 40 healthy controls.
Peripapillary RNFL and mGCC were measured. Correlation analyses were performed for
evaluation of association between pRNFL or mGCC and PD severity using the Movement
Disorder Society (MDS)-Unified Parkinson Disease Rating Scale (UPDRS). Scatterplots
were used to evaluate relationships between disease duration, dopamine dose, olfactory
assessment and retinal thickness.
Results
No significant difference was found for both eyes of PD patients compared to healthy
subjects neither for overall mGCC nor each sector. However, the ipsilateral eye to
the most-affected body side with bradykinesia in PD patients had a statistically significant
thinner superior pRNFL compared to healthy controls (P = 0.03). There was no significant
correlation between pRNFL or mGCC and disease severity; also, the scatterplots did
not indicate a correlation between disease duration, dopamine dose, olfactory testing
and OCT results.
Conclusions
Imaging of the retina revealed thinning of some retinal layers of the ipsilateral
eye to the most-affected body side in PD patients compared to healthy controls. Peripapillary
RNFL and mGCC did not correlate to disease severity; however, this was a fairly small
and heterogeneous group of PD patients.
Keywords
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Article info
Publication history
Published online: June 13, 2018
Accepted:
June 9,
2018
Received in revised form:
May 6,
2018
Received:
December 5,
2017
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
