Highlights
- •Suicidal ideation is increased in Parkinson's disease.
- •Suicidal ideation has a multi-factorial origin in Parkinson's disease.
- •Perceived disability plays has a key role in parkinsonian suicidal ideation.
Abstract
Introduction
Suicidal ideation is increased in Parkinson's disease (PD) patients. The possible
relationship between parkinsonian motor and non-motor symptoms and suicidal ideation
in PD is unknown. The aim of the study was to evaluate suicidal ideation in patients
with PD in a controlled study specifically designed to identify the clinical correlates
of PD suicidal ideation.
Methods
We consecutively enrolled 100 patients with PD, 76 patients with psoriasis and 80
healthy subjects. Motor symptoms and complications were evaluated by using the International
Parkinson and Movement Disorder Society-Unified Parkinson's Disease Rating Scale.
Non-motor symptoms were evaluated by means of the Non-Motor Symptoms assessment scale
for PD. All patients also underwent a psychiatric evaluation that included the administration
of the Columbia-Suicide Severity Rating Scale.
Results
Suicidal ideation was present in 31% of PD patients, 16% of patients with psoriasis
and 2% of healthy controls. PD patients showing suicidal ideation have more frequent
motor complications, more severe non-motor symptoms and a higher perceived disability
than patients without suicidal ideation. Suicidal ideation correlated with the presence
of motor complications as well as with non-motor symptom severity, perceived disability
severity and the presence of psychiatric disorders.
Conclusions
Our findings showed that suicidal ideation is increased in PD patients compared with
healthy controls and patients with psoriasis and that several clinical PD features,
including motor complications and non-motor symptoms, are associated with suicidal
ideation in PD. The results suggest a multi-factorial origin of PD suicidal ideation.
Keywords
Abbreviations:
C-SSRS (Columbia Suicide Severity Rating Scale), FAB (Frontal Assessment Battery), H&Y (Hoehn and Yahr scale), IDPS (Italian Perceived Disability Scale), LEDDs (levodopa-equivalent daily dose), MoCA (Montreal Cognitive Assessment), MDS (UPDRS), Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (NMSS), Non-Motor Symptoms assessment scale for Parkinson's disease (PD:Parkinson's disease)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: March 03, 2019
Accepted:
February 27,
2019
Received in revised form:
February 26,
2019
Received:
August 19,
2018
Identification
Copyright
© 2019 Elsevier Ltd. All rights reserved.
