Highlights
- •Non-motor symptoms (NMS) are frequent in Parkinson's disease (PD) patients during the first steps of the disease.
- •Health-related and global perceived quality of life (QoL) are worse in PD patients than controls.
- •Strong correlation was observed between PQ-10 and EUROHIS-QOL8, both scales to provide global QoL.
- •NMS burden, mood, and gait problems are the most significant factors contributing to a worse QoL.
- •In practice, it is necessary to ask about NMS, mood, and gait problems in PD patients during their first years of evolution.
Abstract
Objective
To identify factors related to a poor health-related and global quality of life (QoL)
in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control
group.
Methods
The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational,
5-year follow-up, multicenter, evaluation study. Three instruments were used to assess
QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective
rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8).
Multiple linear regression methods were used to evaluate the direct impact of different
variables on these QoL measures.
Results
QoL was worse in PD patients (n = 692; 62.6 ± 8.9 years old, 60.3% males) than controls
(n = 206; 61 ± 8.3 years old, 49.5% males): PDQ-39, 17.1 ± 13.5 vs 4.4 ± 6.3 (p < 0.0001);
PQ-10, 7.3 ± 1.6 vs 8.1 ± 1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ± 0.6 vs 4.2 ± 0.5 (p < 0.0001).
A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS)
(r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65;
p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood
(BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest
contribution to the model (β = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas
mood and gait problems contributed the most to global QoL (PQ-10, β = -0.46 and −0.21,
respectively; EUROHIS-QOL8, β = -0.44 and −0.23, respectively).
Conclusions
QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and
gait problems seem to be the most relevant factors affecting health-related and global
perceived QoL in non-demented PD patients.
Keywords
Abbreviations:
ADLS (Schwab & England Activities of Daily Living Scale), BDI, (Beck Depression Inventory-II), EUROHIS-QOL8 (European Health Interview Survey-Quality of Life 8 Item-Index), FOG (freezing of gait), FOGQ (freezing of gait Questionnaire), GQoL (Global quality of life), HRQoL (health-related quality of life), H&Y (Hoenh & Yahr), NMS (non-motor symptoms), NMSS (Non-Motor Symptoms Scale), NPI (Neuropsychiatric Inventory), PD (Parkinson's disease), PD-CRS (Parkinson's Disease Cognitive Rating Scale), PDQ-39SI (39-item Parkinson's Disease Quality of Life Questionnaire Summary Index), PDSS (Parkinson's Disease Sleep Scale), QoL (Quality of life), QUIP-RS (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale), UPDRS (Unified Parkinson's Disease Rating Scale), VAFS (Visual Analog Fatigue Scale), VAS-Pain (Visual Analog Scale-Pain)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: July 29, 2019
Accepted:
July 27,
2019
Received in revised form:
January 18,
2019
Received:
October 12,
2018
Identification
Copyright
© 2019 Elsevier Ltd. All rights reserved.
