Advertisement

Primary progressive apraxia of speech: A further piece in the progressive supranuclear/corticobasal degeneration spectrum jigsaw

  • Gesine Respondek
    Correspondence
    Corresponding author.
    Affiliations
    Dept. of Neurology, Hannover Medical School, Hannover, Germany
    Search for articles by this author
  • Yaroslau Compta
    Correspondence
    Corresponding author. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
    Affiliations
    Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain

    Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona. Institute of Neuroscience, University of Barcelona, Barcelona, Catalonia, Spain

    Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
    Search for articles by this author
      Extensive research has been dedicated to comprehensively describe clinical and pathological characteristics of neurodegenerative diseases for more than a century. Surprisingly, there are still conditions that remain largely unexplored. A good example is primary progressive apraxia of speech (PPAOS), a neurodegenerative syndrome presenting with a primary progressive motor speech disorder. Although PPAOS likely has a prevalence of more than 4/100.000 [
      • Whitwell J.L.
      • Duffy J.R.
      • Strand E.A.
      • Machulda M.M.
      • Tosakulwong N.
      • Weigand S.D.
      • Senjem M.L.
      • Spychalla A.J.
      • Gunter J.L.
      • Petersen R.C.
      • Jack C.R.
      • Josephs K.A.
      Sample size calculations for clinical trials targeting tauopathies: a new potential disease target.
      ], it was not considered a separate clinical syndrome until recently.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Parkinsonism & Related Disorders
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Whitwell J.L.
        • Duffy J.R.
        • Strand E.A.
        • Machulda M.M.
        • Tosakulwong N.
        • Weigand S.D.
        • Senjem M.L.
        • Spychalla A.J.
        • Gunter J.L.
        • Petersen R.C.
        • Jack C.R.
        • Josephs K.A.
        Sample size calculations for clinical trials targeting tauopathies: a new potential disease target.
        J. Neurol. 2015; 262: 2064-2072https://doi.org/10.1007/s00415-015-7821-5
        • Josephs K.A.
        • Duffy J.R.
        • Strand E.A.
        • Whitwell J.L.
        • Layton K.F.
        • Parisi J.E.
        • Hauser M.F.
        • Witte R.J.
        • Boeve B.F.
        • Knopman D.S.
        • Dickson D.W.
        • Jack C.R.
        • Petersen R.C.
        Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech.
        Brain. 2006; https://doi.org/10.1093/brain/awl078
        • Höglinger G.U.
        • Respondek G.
        • Stamelou M.
        • Kurz C.
        • Josephs K.A.
        • Lang A.E.
        • Mollenhauer B.
        • Müller U.
        • Nilsson C.
        • Whitwell J.L.
        • Arzberger T.
        • Englund E.
        • Gelpi E.
        • Giese A.
        • Irwin D.J.
        • Meissner W.G.
        • Pantelyat A.
        • Rajput A.
        • van Swieten J.C.
        • Troakes C.
        • Antonini A.
        • Bhatia K.P.
        • Bordelon Y.
        • Compta Y.
        • Corvol J.-C.
        • Colosimo C.
        • Dickson D.W.
        • Dodel R.
        • Ferguson L.
        • Grossman M.
        • Kassubek J.
        • Krismer F.
        • Levin J.
        • Lorenzl S.
        • Morris H.R.
        • Nestor P.
        • Oertel W.H.
        • Poewe W.
        • Rabinovici G.
        • Rowe J.B.
        • Schellenberg G.D.
        • Seppi K.
        • van Eimeren T.
        • Wenning G.K.
        • Boxer A.L.
        • Golbe L.I.
        • Litvan I.
        • Boxer A.L.
        • Rajput A.
        • Pantelyat A.
        • Antonini A.
        • Lang A.E.
        • Giese A.
        • Mollenhauer B.
        • Colosimo C.
        • Kurz C.
        • Nilsson C.
        • Troakes C.
        • Irwin D.J.
        • Dickson D.W.
        • Gelpi E.
        • Krismer F.
        • Schellenberg G.D.
        • Respondek G.
        • Rabinovici G.
        • Wenning G.K.
        • Höglinger G.U.
        • Morris H.R.
        • Litvan I.
        • Rowe J.B.
        • Kassubek J.
        • Corvol J.-C.
        • Whitwell J.L.
        • Levin J.
        • van Swieten J.
        • Bhatia K.P.
        • Josephs K.A.
        • Seppi K.
        • Golbe L.I.
        • Stamelou M.
        • Grossman M.
        • Nestor P.
        • Dodel R.
        • Lorenzl S.
        • van Eimeren T.
        • Arzberger T.
        • Müller U.
        • Meissner W.G.
        • Poewe W.
        • Oertel W.H.
        • Compta Y.
        • Bordelon Y.
        Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria.
        Mov. Disord. 2017; 32https://doi.org/10.1002/mds.26987
        • Seckin Zeynep I.
        • Duffy Joseph R.
        • Strand Edythe A.
        • Clark Heather M.
        • Utianski Rene L.
        • Machulda Mary M.
        • Botha H.
        • Ali F.
        • Pham N.T.T.
        • Lowe Val J.
        • Whitwell Jennifer L.
        • Josephs Keith A.
        The evolution of parkinsonism in primary progressive apraxia of speech: a 6-year longitudinal study.
        Park. Relat. Disord. 2020; 81: 34-40https://doi.org/10.1016/j.parkreldis.2020.09.039
        • Armstrong M.J.
        • Litvan I.
        • Lang A.E.
        • Bak T.H.
        • Bhatia K.P.
        • Borroni B.
        • Boxer A.L.
        • Dickson D.W.
        • Grossman M.
        • Hallett M.
        • Josephs K.A.
        • Kertesz A.
        • Lee S.E.
        • Miller B.L.
        • Reich S.G.
        • Riley D.E.
        • Tolosa E.
        • Troster A.I.
        • Vidailhet M.
        • Weiner W.J.
        Criteria for the diagnosis of corticobasal degeneration.
        Neurology. 2013; 80: 496-503https://doi.org/10.1212/WNL.0b013e31827f0fd1
        • Kovacs G.G.
        • Lukic M.J.
        • Irwin D.J.
        • Arzberger T.
        • Respondek G.
        • Lee E.B.
        • Coughlin D.
        • Giese A.
        • Grossman M.
        • Kurz C.
        • McMillan C.T.
        • Gelpi E.
        • Compta Y.
        • van Swieten J.C.
        • Laat L.D.
        • Troakes C.
        • Al-Sarraj S.
        • Robinson J.L.
        • Roeber S.
        • Xie S.X.
        • Lee V.M.-Y.
        • Trojanowski J.Q.
        • Höglinger G.U.
        Distribution patterns of tau pathology in progressive supranuclear palsy.
        Acta Neuropathol. 2020; 140: 99-119https://doi.org/10.1007/s00401-020-02158-2
        • Narasimhan S.
        • Guo J.L.
        • Changolkar L.
        • Stieber A.
        • McBride J.D.
        • Silva L.v.
        • He Z.
        • Zhang B.
        • Gathagan R.J.
        • Trojanowski J.Q.
        • Lee V.M.Y.
        Pathological tau strains from human brains recapitulate the diversity of tauopathies in nontransgenic mouse brain.
        J. Neurosci. 2017; 37: 11406-11423https://doi.org/10.1523/JNEUROSCI.1230-17.2017