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The effect of Origanum majorana tea on motor and non-motor symptoms in patients with idiopathic Parkinson's disease: A randomized controlled pilot study

  • Chbili Chahra
    Correspondence
    Corresponding author. Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine Ibn El Jazzar Sousse, Sousse University, Tunisia.
    Affiliations
    Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine Ibn El Jazzar Sousse, Sousse University, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Hassine Anis
    Affiliations
    Neurology Department, Sahloul Teaching Hospital, Sousse, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Douma Bissene
    Affiliations
    Neurology Department, Sahloul Teaching Hospital, Sousse, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Selmi Mejda
    Affiliations
    Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine Ibn El Jazzar Sousse, Sousse University, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Maatoug Jihène
    Affiliations
    Department of Epidemiology, University Hospital Farhat Hached, Sousse, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Naija Salma
    Affiliations
    Neurology Department, Sahloul Teaching Hospital, Sousse, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Nouira Manel
    Affiliations
    Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine Ibn El Jazzar Sousse, Sousse University, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Ben Amor Sana
    Affiliations
    Neurology Department, Sahloul Teaching Hospital, Sousse, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Khairi Hedi
    Affiliations
    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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  • Ben Fredj Maha
    Affiliations
    Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine Ibn El Jazzar Sousse, Sousse University, Tunisia

    University of Sousse, Faculty of Medicine Ibn El Jazzar, Sousse, Tunisia
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      Highlights

      • Origanum marjorana tea significantly improved non-motor symptoms as attested by BDI and NMSS scores.
      • A decrease in the UPDRS part III total score was observed, but this effect was not significant.
      • Origanum marjorana tea could improve non-motor Parkinson's disease symptoms.

      Abstract

      Aims

      The effect of Origanum majorana tea consumption on motor and non-motor symptoms was investigated in patients with idiopathic Parkinson's disease, measured by validated tools.

      Methods

      Sixty patients with idiopathic Parkinson's disease and under conventional medication were enrolled voluntarily in the study. All participants were randomized on double-blind to placebo or Origanum majorana. Clinical assessment with validated tools (UPDRSIII, NMSS, and BDI) was done before Origanum majorana or placebo consumption (Day 0) and at the end of the experiment (Day 30).

      Results

      The treatment groups were similar at baseline on demographic and clinical variables. During the course of study, nine participants withdrew for reasons of noncompliance and inability to follow-up. Fifty-one participants completed the study. Upon completion of 30 days of treatment, Origanum majorana tea consumption did not decrease the UPDRSIII score ([UPDRSIII] D0 = 18.76 ± 8.58, D30 = 16.52 ± 7.96, p = 0.069) at the p value was 0.07. However, a statistically significant improvement was noted in NMSS and BDI scores (p < 0.0001 and p < 0.0001, respectively). Assessment of the UPDRSIII, NMSS and BDI scores of the patients did not reflect any improvement with placebo. No side effect was detected during the study.

      Conclusion

      These findings show improvement of depressive and non-motor signs in patients with Parkinson's disease in the group that consumed Origanum majorana tea in combination with conventional therapy. Improvement of motor signs may need an extended treatment period. However, more research with a large number of participants and lasting longer than 1 month is needed to argue these findings.

      Keywords

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