To determine phenotypic differences between Black and White patients with Parkinson's
Design/Methods: Patients with PD in a movement disorders clinic were approached to
participate. After consent, a battery of tests was completed, including MDS-UPDRS
Part III and the motor domains of the NIH Toolbox, Montreal Cognitive Assessment,
Single Digit Modality Test, Patient-Reported Outcomes Measurement Information System
(PROMIS) measures, Parkinson's Disease Questionnaire (PDQ39), Schwab and England,
Epworth Sleepiness Scale, UPSIT smell test, and others.
Twenty-four Black PD and 25 White PD patients participated. There were no differences
in demographics and MDS-UPDRS Part III scores. White PD participants performed better
on the 4-m walk gait speed test (p < 0.0005), standing balance test (p < 0.001), Montreal
Cognitive Assessment (p < 0.0005), and Single Digit Modality Test (p < 0.005). Black
PD participants had lower scores on PROMIS Satisfaction with Participation (p = 0.023),
PROMIS Physical Function Mobility (p = 0.007), total PDQ39 (p = 0.008), PDQ39 mobility
(p = 0.012), PDQ39 ADL (p = 0.014), PDQ39 cognition (p = 0.023), and PDQ39 body discomfort
(p = 0.041) scales.
Significant differences were found in motor, non-motor and quality of life scales
in Black and White PD participants with similar demographics. Further work will need
to be done to identify the underlying reasons and ways to mitigate these disparities.