A late-onset neurological disorder: is progression inevitable?

      An 88-year-old right-handed man with a history of coronary artery disease and recurrent presyncopal events associated with palpitations presented with a 2-year history of slowly progressive left-hand clumsiness, tremor and gait disturbance.


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        • Yousry T.A.
        • Schmid U.D.
        • Alkadhi H.
        • Schmidt D.
        • Peraud A.
        • Buettner A.
        • Winkler P.
        Localization of the motor hand area to a knob on the precentral gyrus. A new landmark.
        Brain. 1997; 120: 141-157
        • Armstrong M.J.
        • Litvan I.
        • Lang A.E.
        • et al.
        Criteria for the diagnosis of corticobasal degeneration.
        Neurology. 2013; 80: 496-503
        • Boeve B.
        • Lang A.E.
        • Litvan I.
        Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia.
        Ann. Neurol. 2003; 54: S15-S19
        • Dunalska A.
        • Pikul J.
        • Schok K.
        • Wiejak K.A.
        • Alster P.
        The significance of vascular pathogenesis in the examination of corticobasal syndrome.
        Front. Ageing Neurosci. 2021; 13668614
        • Kreisler A.
        • Mastain B.
        • Tison F.
        • Fenelon G.
        • Destee A.
        [Multi-infarct disorder presenting as corticobasal degeneration (DCB): vascular pseudo-corticobasal degeneration?.
        Rev. Neurol. (Paris). 2007; 163: 1191-1199
        • Koga S.
        • Roemer S.
        • Kasanuki K.
        • Dickson D.
        Cerebrovascular pathology presenting as corticobasal syndrome: an autopsy case series of “vascular CBS”.
        Park. Relat. Disord. 2019; 68: 79-84
        • Martino D.
        • Chew N.K.
        • Mir P.
        • Edwards M.J.
        • Quinn N.P.
        • Bhatia K.P.
        Atypical movement disorders in antiphospholipid syndrome.
        Mov. Disord. 2006; 21: 944-949
        • Lee D.W.
        • Eum S.W.
        • Moon C.O.
        • Ma H.I.
        • Kim Y.J.
        Corticobasal syndrome associated with antiphospholipid syndrome without cerebral infarction.
        Neurology. 2014; 82: 730-731
        • Takase K.I.
        • Matsumoto S.
        • Nishi H.
        • Nakahara I.
        A case of superior sagittal sinus intracranial dural arteriovenous fistula mimicking corticobasal syndrome.
        J. Neurol. Sci. 2017; 376: 91-92
        • Miyaji Y.
        • Koyama K.
        • Kurokawa T.
        • Mitomi M.
        • Suzuki Y.
        • Kuroiwa Y.
        Vascular corticobasal syndrome caused by unilateral internal carotid artery occlusion.
        J. Stroke Cerebrovasc. Dis. 2013; 22: 1193-1195
        • Vitt J.R.
        • Hamedani A.G.
        • Horn S.
        • Gannon K.P.
        • Price R.S.
        • Greene M.
        Acquired hemicerebral atrophy secondary to chronic internal carotid steno-occlusive disease: a case series.
        The Neurohospitalist. 2020; 10: 38-42