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Characterization of the central motor conduction time in a large cohort of spinocerebellar ataxia type 3 patients

  • Yuting Shi
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
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  • Linliu Peng
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
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  • Guangdong Zou
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
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  • Zhao Chen
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China

    National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China
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  • Linlin Wan
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China

    National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China
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  • Zhichao Tang
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
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  • Xuan Hou
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
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  • Huirong Peng
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
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  • Chunrong Wang
    Affiliations
    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China

    Department of Pathology, Xiangya Hospital, Central South University, Changsha, China
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  • Lu Shen
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China

    National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China
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  • Kun Xia
    Affiliations
    Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China

    Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, China
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  • Rong Qiu
    Affiliations
    School of Computer Science and Engineering, Central South University, Changsha, China
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  • Beisha Tang
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China

    National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China

    Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, China
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  • Hong Jiang
    Correspondence
    Corresponding author. Department of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
    Affiliations
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

    Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China

    National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China

    Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, China

    School of Basic Medical Science, Central South University, Changsha, China
    Search for articles by this author

      Highlights

      • A small proportion of the SCA3 patients exhibited slightly prolonged CMCT to lower limbs, but not upper limbs, which was uncorrelated with disease severity.
      • The CMCT to lower limbs in healthy controls was positively correlated with body height.
      • CMCT measures were observed irrespective of pyramidal sign in SCA3, however, patients with abnormal CMCT had a higher incidence of pyramidal sign.

      Abstract

      Introduction

      Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of hereditary ataxia. Few studies reported the CMCT features in SCA3, but with inconsistent findings. So far, CMCT in SCA3 remains largely unknown.

      Methods

      This study included 86 SCA3 patients and 80 healthy controls. Motor-evoked potentials were recorded bilaterally from upper and lower limbs muscles by TMS using a double-cone coil attached to CCY-IA magnetic stimulator. CMCT was determined using F wave and paravertebral magnetic stimulation (PMS). The statistical analyses were performed using R software.

      Results

      In our study, 36.5% of SCA3 patients had a slight prolongation of CMCT in lower limbs, but not upper limbs, uncorrelated with disease severity. Moreover, SCA3 patients with Babinski signs did not necessarily have abnormal CMCT, and vice versa. Our study demonstrated that PMS is a reliable method as F wave for detecting CMCT in SCA3. Additionally, CMCT to lower limbs was positively correlated with height, but not with age, sex, or weight in healthy controls.

      Conclusions

      A small proportion of SCA3 patients had a slight prolongation of CMCT in lower limbs, but not upper limbs, uncorrelated with disease severity. Furthermore, CMCT measures were observed irrespective of pyramidal sign in SCA3; however, patients with abnormal CMCT had a higher incidence of the pyramidal sign.

      Keywords

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