Deep brain stimulation in dopa-responsive parkinsonism – Look out for red flags


      • It is important to look for red flags in a patient suspected to have PD especially when DBS is being considered.
      • This report highlights the dopa-responsive parkinsonism presentation as a part of the AP5Z1 clinical spectrum.
      • The SPG11 and SPG15 proteins are known to interact with AP-5 suggesting a common molecular mechanism at work with AP5Z1-related SPG48.
      • Dopa-responsive parkinsonism is reported in SPG11 and SPG15 as well.


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