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Evaluation of serum hepcidin concentrations in Parkinson’s disease patients

      Objective: Parkinson’s disease (PD) is characterized by the deposition of inclusion bodies (Lewy bodies) of α-synuclein in substantia nigra, which is ubiquitously expressed in the brain and mutations in this protein are presented in familial forms of AD. Dopamine as a neurotransmitter, and at the same time is a very good metal chelator and electron donor that define the conditions in vivo generation of toxic free radicals. It has a high propensity to coordinate with Cu2+ and Fe3+ and reduce metal primer Fenton generation of H2O2.
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