- Movement disorders comprise a range of physically and emotionally debilitating conditions which profoundly impact daily activities. Most are associated with significant reductions in quality of life (QOL), which itself is a multidimensional construct influenced not only by physical impairment but also by psychological factors, patient resilience, social support and coping strategies. Maintaining maximal QOL in the face of disease-related challenges is a major focus of movement disorder practice.
- Benign tremulous parkinsonism is generally considered a disease of the elderly, characterised by dominance of tremor over other motor manifestations, and by slower disease progression. Herein, we draw attention to a different clinical syndrome, benign tremulous parkinsonism of the young, which we have observed in Parkin disease.
- To characterise the distinctive eye movement disorder and the sleep-related dyskinesia in Adenylate cyclase 5 (ADCY5) related disease.
- We read with great interest the publication by Rajput and colleagues, reporting the autopsy findings of five couples with conjugal parkinsonism (including three with atypical parkinsonism like multisystem atrophy (MSA) or progressive supranuclear palsy (PSP), but only two with Parkinson's disease) and concluding that neither a prion-like transmission nor shared environmental factor seem to play a role in the pathogenesis of Parkinson's disease . They further suggest that the risk of parkinsonism in unrelated couples is similar to that in the general population.