- Hereditary spastic paraplegia is a heterogeneous group of genetic disorders characterized by degeneration of the corticospinal tracts, coursing with progressive weakness and spasticity of the lower limbs. To date, there are no effective treatments for progressive deficits or disease-modifying therapy for those patients. We report encouraging results for spastic paraparesis after spinal cord stimulation.
- Freezing of gait (FOG) is a disabling, episodically occurring symptom in patients with advanced Parkinson's disease (PD) and atypical parkinsonian syndromes. FOG is typically triggered by gait initiation, turning, passing through narrow paths such as doorways, and reaching a destination. Although medication, deep brain stimulation and non-pharmacological strategies such as cueing may be helpful in some patients, therapeutic options are limited. The phenomenology and pathophysiology is still not fully understood.
- The pathophysiology of dysphagia in Parkinson's disease (PD) is heterogeneous and poorly understood at present. This study investigated the phenotypes, prevalence and pathophysiology of oropharyngeal freezing (OPF) in PD and its relation to dysphagia.
- Freezing of gait (FOG) in Parkinson's disease (PD) is disabling and frequently treatment-resistant . Cueing is initially effective but requires training, special devices and may paradoxically elicit FOG . Turning is the most common FOG trigger , however, few studies have focused on strategies specifically targeting FOG while turning (turning-FOG) [4,5]. Here, we present jumping as a potential strategy for selected PD patients to overcome treatment-resistant turning-FOG.
- In advanced Parkinson's disease (PD), axial symptoms such as speech, gait, and balance impairment often become levodopa-unresponsive and they are difficult to manage, even in patients with subthalamic nucleus deep brain stimulation (STN-DBS). We anecdotally observed that oral administration of amantadine was very effective in treating both residual and stimulation-induced axial symptoms after bilateral STN-DBS in one PD patient. Therefore, we conducted a prospective multicenter observational study to evaluate the effects of amantadine on speech, gait and balance in PD patients with STN-DBS and incomplete axial benefit.